Role of endothelium in the control of arterial diameter by blood flow.
Role of endothelium in the control of arterial diameter by blood flow.
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内皮细胞在血流控制动脉直径中的作用。
DOI：
10.1159/000158609
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
S. Doležel
中科院分区：
文献类型：
--
作者：
V. Smiěsko;J. Kozík;S. Doležel
导管动脉对血流增加的扩张反应已被证明是由局部机制引起的[1，2]，而不是由外周血管区域的松弛扩散引起的[3]。为了寻找局部机制的触发信号，内皮细胞被认为配备了对血流产生的切应力敏感的受体[4]，本研究的目的是从实验上检验内皮在血流控制动脉内径中是否起着如此关键的作用。实验在19只杂种犬上进行，雌雄各半(体重10-16公斤)，用硫喷妥钠(Spofa)麻醉，起始剂量为15 mg·kg-1。补充剂量7 mg·kg~(-1)·h~(-1)。显露腹股沟韧带远端的股动脉，其周端用塑料管与对侧股静脉相连。足总位于被切割的边缘形成的槽中
The dilator response of a conduit artery to an increase in blood flow has been proved to be caused by a local mechanism [1, 2] and not by spreading of relaxation from the pe ripheral vascular area [3]. Searching for a trigger signal of the local mechanism the en dothelial cells have been supposed to be equipped with receptors sensitive to the shear stress produced by the flow of blood [4], The purpose of this study was to examine experi mentally whether the endothelium plays such a key role in the control of arterial diameter by blood flow.The experiments were performed on 19 mongrel dogs of both sexes (body weight 10-16 kg) anesthetized with sodium thiopental (Spofa), the initial dose being 15 mg-kg-1, the supplementary doses 7 mg-kg-1-h* 1. The fe moral artery (FA) distal to the inguinal liga ment was exposed and its peripheral end was connected by a plastic tube to the contralat eral femoral vein. The FA was situated in a trough formed by the edges of the incised