Synthesis and characterization of folate decorated albumin bio-conjugate nanoparticles loaded with a synthetic curcumin difluorinated analogue
Synthesis and characterization of folate decorated albumin bio-conjugate nanoparticles loaded with a synthetic curcumin difluorinated analogue
复制标题
DOI：
10.1016/j.jcis.2017.01.092
复制
发表时间：
2017-06-15
影响因子：
9.9
通讯作者：
Iyer, Arun K.
中科院分区：
文献类型：
--
作者：
Gawde, Kaustubh A.;Kesharwani, Prashant;Iyer, Arun K.
白蛋白结合的紫杉醇胶体纳米颗粒（Abraxane（（R）是FDA批准的可在市场上获得的抗癌制剂。它是一种目前用于治疗乳腺癌、肺癌和胰腺癌等的悬浮液。CDF是一种新型的、有效的合成姜黄素类似物，广泛用于乳腺癌和卵巢癌。本研究的目的是使用生物相容性的白蛋白以及叶酸修饰的白蛋白，以形成包裹二氟化姜黄素（CDF）的胶体纳米粒。与其天然衍生物姜黄素相比，CDF的稳定性提高了16倍，抗癌效力显著。CDF通过下调多种miRNA、上调磷酸酶和张力蛋白同源物（PTEN）以及减弱组蛋白甲基转移酶EZH2显示出显著的癌细胞生长抑制。然而，CDF是高度疏水性和光降解性的，具有少量的水溶性。在这项研究中，我们制定了白蛋白
Albumin-bound paclitaxel colloidal nanoparticle (Abraxane((R))) is an FDA approved anticancer formulation available in the market. It is a suspension which is currently used therapeutically for treating cancers of the breast, lung, and pancreas among others. CDF is a novel new and potent synthetic curcumin analogue that is widely used for breast and ovarian cancer. The aim of this study was to use biocompatible albumin as well as folate decorated albumin to formulate colloidal nanoparticles encapsulating curcumin difluorinated (CDF). CDF has demonstrated a 16-fold improvement in stability and remarkable anticancer potency compared to its natural derivative, curcumin. CDF showed marked inhibition of cancer cell growth through down-regulation of multiple miRNAs, up-regulation of phosphatase and tensin homolog (PTEN), and attenuation of histone methyl transferase EZH2. However, CDF is highly hydrophobic and photodegradable with sparing aqueous solubility. In this study, we have formulated albumin