The interaction of 5-fluorouracil, hydroxyurea, and radiation in two human head and neck cancer cell lines.
The interaction of 5-fluorouracil, hydroxyurea, and radiation in two human head and neck cancer cell lines.
复制标题
5-氟尿嘧啶、羟基脲和辐射在两种人头颈癌细胞系中的相互作用。
DOI：
10.1159/000227092
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发表时间：
1992
期刊：
影响因子：
3.5
通讯作者：
Weichselbaum,RR
中科院分区：
文献类型：
--
作者：
Vokes,EE;Beckett,M;Karrison,T;Weichselbaum,RR
我们研究了 5-氟尿嘧啶 (5-FU) 和羟基脲 (HU) 辐射对两种人头颈鳞状癌细胞系的影响。 SQ-20B 的 D₀ 为 239 cGy，S 相分数为 37%，而 SQ-38 的 D₀ 为 146 cGy，S 相分数为 31%。对于 SQ-20B，当细胞暴露于 HU 或 5-FU 或两种化疗药物与放疗一起时，100 cGy 下的存活分数显着降低 (p < 0.05)。与单独放疗相比，SQ-38 单独使用化疗药物或与放疗联合使用时均未发现显着效果。因此，仅在具有较高 DO 和较高 S 期分数的头颈癌细胞系中观察到 5-FU 和 HU 与放疗之间的附加细胞毒性。
We have investigated the effects of 5-fluorouracil (5-FU) and hydroxyurea (HU) with radiation on two human head and neck squamous carcinoma cell lines. SQ-20B has a D₀ of 239 cGy and an S phase fraction of 37%, while SQ-38 has a D₀ of 146 cGy and an S phase fraction of 31 %. For SQ-20B the surviving fraction at 100 cGy was significantly reduced (p < 0.05) when cells were exposed to HU or to 5-FU or both chemotherapy agents together with radiation. No significant effect was seen for SQ-38 with either chemotherapy agent alone or in combination with radiation as compared with radiation alone. Therefore, additive cytotoxicity between 5-FU and HU and radiotherapy was observed only in a head and neck cancer cell line with a higher DO and a higher S phase fraction.