Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells
Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells
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DOI：
10.1086/378503
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发表时间：
2003-10-01
影响因子：
6.4
通讯作者：
Exley, M
中科院分区：
文献类型：
--
作者：
Levy, O;Orange, JS;Exley, M
一名11岁的女孩在接受水痘疫苗接种5周后出现丘疹水疱性皮疹和严重呼吸窘迫。限制性片段长度多态性分析的病毒分离气管内管吸出物和支气管肺泡灌洗液显示，该患者的疾病是由于奥卡水痘疫苗株。广泛的免疫学分析未能确定一个已知的诊断实体来解释她对这种减毒疫苗株的易感性。她的淋巴细胞在不同场合的分析，从她的疾病康复后几个月，揭示了自然杀伤T（NKT）细胞和NKT细胞活性的严重缺乏，这表明NKT细胞有助于宿主防御水痘病毒。
An 11-year-old girl presented with a papulovesicular rash and severe respiratory distress 5 weeks after receiving varicella vaccine. Restriction fragment length - polymorphism analysis of virus isolated from an endotracheal-tube aspirate and from bronchoalveolar lavage revealed that this patient's illness was due to the Oka vaccine strain of varicella. An extensive immunologic analysis failed to identify a known diagnostic entity to explain her susceptibility to this attenuated vaccine strain. Analysis of her lymphocytes on separate occasions, months after recovery from her illness, revealed a profound deficiency of natural killer T (NKT) cells and of NKT-cell activity, suggesting that NKT cells contribute to host defense against varicella virus.