Histologic changes produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the skin of mice carrying mutations that affect the integument.
Histologic changes produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the skin of mice carrying mutations that affect the integument.
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2,3,7,8-四氯二苯并-对二恶英在携带影响体皮突变的小鼠皮肤中产生的组织学变化。
DOI：
10.1111/1523-1747.ep12273574
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Glover,E
中科院分区：
文献类型：
--
作者：
Poland,A;Knutson,JC;Glover,E
2，3，7，8-四氯二苯并-对-二恶英（TCDD）在8种具有隐性突变无毛（hr/hr）的小鼠品系中引起表皮增生和角化过度、皮脂腺鳞状化生和角化囊肿形成。这些组织学变化的程度取决于遗传背景。在有毛（hr/+）小鼠中未产生皮肤病变。在检查其他7种影响皮肤的突变小鼠时，TCDD在隐发、裸毛、拔毛和无毛中产生了类似的组织学皮肤变化;在反复脱毛中产生了皮脂腺的边缘鳞状上皮化生，并且对皮毛缺陷和裸毛突变体没有影响。这些遗传决定的表皮反应进行了讨论，根据TCDD的作用机制。
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) produces epidermal hyperplasia and hyperkeratosis, squamous metaplasia of the sebaceous gland, and keratinized cyst formation in 8 strains of mice with the recessive mutation, hairless (hr/hr). The extent of these histologic changes is dependent on the genetic background. No cutaneous lesions are produced in haired (hr/+) mice. In examination of mice with 7 other mutations affecting the integument, TCDD produced similar histologic skin changes in cryptothrix, nude, plucked, and atrichosis; a marginal squamous metaplasia of sebaceous glands in Repeated epilation, and had no effect in fur deficient and Naked mutants. These genetically determined epidermal responses are discussed in light of the mechanism of action of TCDD.