Quality of life in patients with multiple sclerosis: The impact of fatigue and depression
Quality of life in patients with multiple sclerosis: The impact of fatigue and depression
复制标题
DOI：
10.1016/s0022-510x(02)00312-x
复制
发表时间：
2002-12-15
影响因子：
4.4
通讯作者：
Bakshi, R
中科院分区：
文献类型：
--
作者：
Janardhan, V;Bakshi, R
多发性硬化症(MS)患者的生活质量(QOL)受损，部分原因是身体残疾。MS相关性疲劳(MSF)和抑郁(MSD)是MS的常见和可治疗的特征，也可以影响生活质量，与身体残疾无关。我们前瞻性地研究了60名连续的MS患者，使用多发性硬化症生活质量(MSQOL)-54进行了评估。在调整扩展残疾状态量表(EDSS)、疲劳严重程度量表(FSS)和汉密尔顿抑郁问卷评分后，评估两组患者生活质量评分的差异。MS患者分为复发缓解型(RR)或继发性进展型(SP)、MSF(FSS大于或等于5)或MS无疲劳型(MSNF)(FSS小于或等于4)、MSD或MS无抑郁(MSND)。在考虑了残疾和抑郁后，疲劳与健康感知方面的生活质量受损(p=0.03)和由于身体功能障碍造成的限制(p=0.008)有关。在考虑了残疾和疲劳后，抑郁症与以下方面的生活质量降低有关：健康知觉(p=0.02)、性功能障碍(p=0.03)、健康困扰(p=0.03)、精神健康(p=0.006)、总体生活质量(p=0.006)、情绪功能障碍(p=0.04)和因情绪功能障碍造成的限制(p=0.03)。这项研究表明，在考虑了身体残疾后，疲劳和抑郁与MS患者的生活质量受损独立相关，这表明对它们的认识和治疗可能会改善生活质量。(C)2002 Elsevier Science B.V.保留所有权利。
Quality of Life (QOL) is impaired in multiple sclerosis (MS) in part due to physical disability. MS-associated fatigue (MSF) and depression (MSD) are common and treatable features of MS, which could also impact on QOL, independent of physical disability. We prospectively studied 60 consecutive patients with MS. QOL was assessed using Multiple Sclerosis Quality of Life (MSQOL)-54. Group differences in QOL scores were assessed after adjusting for Expanded Disability Status Scale (EDSS), Fatigue Severity Scale (FSS) and Hamilton Depression Inventory scores. MS patients were grouped into relapsing-remitting (RR) or secondary-progressive (SP), MSF (FSSgreater than or equal to5) or MS-nonfatigue (MSNF) (FSSless than or equal to4), and MSD or MS-nondepression (MSND). After accounting for disability and depression, fatigue was associated with impaired QOL with respect to health perception (p=0.03) and limitations due to physical dysfunction (p=0.008). After accounting for disability and fatigue, depression was associated with lower QOL with respect to health perception (p=0.02), sexual dysfunction (p=0.03), health distress (p=0.03), mental health (p=0.006), overall QOL (p=0.006), emotional dysfunction (p=0.04), and limitations due to emotional dysfunction (p=0.03). This study demonstrates that fatigue and depression are independently associated with impaired QOL in MS, after accounting for physical disability, suggesting that their recognition and treatment can potentially improve QOL. (C) 2002 Elsevier Science B.V. All rights reserved.