Evolution of insect P450
Evolution of insect P450
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DOI：
10.1042/bst0341252
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发表时间：
2006-12-01
影响因子：
3.9
通讯作者：
Feyereisen, R.
中科院分区：
文献类型：
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作者：
Feyereisen, R.
第一个完全测序的昆虫基因组是果蝇和蚊子的基因组，两者都来自双翅目。随着昆虫基因组数量和多样性的不断增加，人们可以更好地理解昆虫P450基因的多样性，并对昆虫细胞色素P450超家族的进化提出初步设想。昆虫P450基因在昆虫纲分化之前存在四个大的进化枝，并且在脊椎动物中也由CYP家族代表：CYP 2进化枝、CYP 3进化枝、CYP 4进化枝和线粒体P450进化枝。P450S具有已知或疑似的生理功能，存在于这些分支中的每一个中，并且在每个昆虫基因组中只有十几个基因似乎具有直向同源物或非常接近的旁系同源物。来自这些进化枝中的每一个的P450酶都与杀虫剂抗性或天然产物和异生物质的代谢有关。特别是，昆虫似乎保持了线粒体P450旁系同源物的所有组成部分，致力于对环境挑战的响应。
The first fully sequenced insect genomes were those of the fruitfly and the mosquito, both from the order Diptera. Now, with an increasing number and diversity of insect genomes becoming available, the diversity of insect P450 genes can be better appreciated and tentative ideas about the evolution of the CYP (cytochrome P450) superfamily in insects can be proposed. There are four large clades of insect P450 genes that existed before the divergence of the class Insecta and that are also represented by CYP families in vertebrates: the CYP2 clade, the CYP3 clacle, the CYP4 clade and the mitochondrial P450 clade. P450S with known or suspected physiological functions are present in each of these clades and only a dozen genes appear to have orthologues or very close paralogues in each insect genome. P450 enzymes from each of these clades have been linked to insecticide resistance or to the metabolism of natural products and xenobiotics. in particular, insects appear to maintain a repertoire of mitochondrial P450 paralogues devoted to the response to environmental challenges.