An update on the pharmacogenomics of metformin: progress, problems and potential.
An update on the pharmacogenomics of metformin: progress, problems and potential.
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DOI：
10.2217/pgs.14.21
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发表时间：
2014-03
期刊：
影响因子：
2.1
通讯作者：
Florez JC
中科院分区：
文献类型：
--
作者：
Todd JN;Florez JC
2型糖尿病患病率的增加强调了优化治疗方案的必要性。二甲双胍是应用最广泛的口服药物，被多个专业组织推荐为一线药物治疗。对二甲双胍的反应在个体水平上差异很大；这种异质性可能部分是由遗传因素解释的。了解这些潜在因素可能有助于为个别患者量身定做治疗方案，也有助于设计改进的2型糖尿病疗法。在过去的10年里，对二甲双胍反应的药物遗传学的理解取得了实质性的进展。这项工作的大部分集中在与二甲双胍药代动力学有关的基因上。由于其作用机制的不确定性，药效遗传学的研究相对较少；全基因组方法有可能阐明二甲双胍反应的分子细节。在这篇综述中，我们总结了目前有关二甲双胍药物遗传学的知识，并对未来的研究方向提出了建议。
The increasing prevalence of Type 2 diabetes has emphasized the need to optimize treatment regimens. Metformin, the most widely used oral agent, is recommended as first-line drug therapy by multiple professional organizations. Response to metformin varies significantly at the individual level; this heterogeneity may be explained in part by genetic factors. Understanding these underlying factors may aid with tailoring treatment for individual patients as well as with designing improved Type 2 diabetes therapies. The past 10 years have seen substantial progress in the understanding of the pharmacogenetics of metformin response. The majority of this work has focused on genes involved in the pharmacokinetics of metformin. Owing to the uncertainty surrounding its mechanism of action, studies of pharmacodynamic genetics have been relatively few; genome-wide approaches have the potential to illuminate the molecular details of metformin response. In this review we summarize current knowledge about metformin pharmacogenetics and suggest directions for future investigation.
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影响因子：
2.6
作者：
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