Variation of lipopolysaccharide-induced acute lung injury in eight strains of mice
Variation of lipopolysaccharide-induced acute lung injury in eight strains of mice
复制标题
DOI：
10.1016/j.resp.2010.02.009
复制
发表时间：
2010-04-30
影响因子：
2.3
通讯作者：
Wang, Xiangdong
中科院分区：
文献类型：
--
作者：
Alm, Ann-Sophie;Li, Ka;Wang, Xiangdong
临床和实验证据表明，遗传变异可能在急性肺损伤（ALI）的发生发展中起重要作用。脂多糖（LPS）诱导的ALI模型已广泛应用于病理生理和药理学研究。为了了解小鼠品系之间急性肺反应的差异，寻找靶向研究的最佳品系，本研究观察了C57 BL/6 J、Balb/cJ、DBA/1 J、CD-1、NMRI、DBA/2 J、A/J和C3 H/HeN小鼠气管内LPS攻击后的结果我们发现，LPS诱导的ALI在测量变量、持续时间和品系之间存在差异。LPS诱导的急性肺过度膨胀、炎症和水肿的一般评分在411时遵循CD-1、A/J、Balb/c、DBA/2 J、C57 BL/6 J、DBA/1 J、NMRI、C3 H/HeN小鼠，并且在24 h时遵循CD-1、C57 BL/6 J、Balb/c、C3 H/HeN、NMRI、A/J、DBA/2 J、DBA/1小鼠。这些数据为筛选敏感或耐药品系小鼠以了解发病机制的遗传变异和筛选靶向药物提供了有用的信息（C）2010 Elsevier B.V All rights reserved.
Clinical and experimental evidence suggests that genetic variations may play an important role in the development of acute lung injury (ALI). Lipopolysaccharide (LPS)-induced ALI models has been widely applied for pathophysiological and pharmacological research. In order to understand the variation of acute pulmonary reactions between mouse strains and find the optimal strain for target-oriented study, the present study investigated the alterations of acute lung hyperinflation, inflammation and injury in C57BL/6J, Balb/cJ, DBA/1J, CD-1, NMRI, DBA/2J, A/J and C3H/HeN mice after the intra-tracheal challenge with LPS We found that LPS-induced ALI varied between measured variables, durations and strains. General score of LPS-induced acute lung hyperinflation, inflammation and edema followed the order CD-1, A/J, Balb/c, DBA/2J, C57BL/6J, DBA/1J, NMRI, C3H/HeN mice at 411, and CD-1, C57BL/6J, Balb/c, C3H/HeN, NMRI, A/J, DBA/2J, DBA/1 mice at 24 h Thus, these data provide useful information to select sensitive or resistant strain mouse for understanding genetic variation of pathogenesis and screening of target-oriented drugs (C) 2010 Elsevier B.V All rights reserved.