Age and Sex Dependence of Forced Expiratory Central Airway Collapse in Healthy Volunteers
Age and Sex Dependence of Forced Expiratory Central Airway Collapse in Healthy Volunteers
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DOI：
10.1378/chest.11-2361
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发表时间：
2012-07-01
期刊：
影响因子：
9.6
通讯作者：
Boiselle, Phillip M.
中科院分区：
文献类型：
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作者：
O'Donnell, Carl R.;Litmanovich, Diana;Boiselle, Phillip M.
背景资料：最近对用力呼气气管塌陷正常范围的估计与早期采用可比测量方法进行的研究有很大不同。鉴于两个样本之间的受试者特征的差异，我们假设，这些差异的结果可能反映了迄今未被认识到的用力呼气气管塌陷和年龄或sex.Methods之间的关联：我们招募了40名女性和41名男性健康志愿者之间的25和75岁的人没有呼吸道症状或已知的危险因素气管软化。受试者在肺总容量（TLC）和强制呼气（Expdyn）期间接受低剂量CT扫描，并进行肺功能监测和指导。结果：TLC和Expdyn的平均气管横截面积（CSA）分别为2.54 cm（2）+/- 0.57 cm（2）和1.15 cm（2）+/- 0.53 cm（2）。平均用力呼气衰竭百分比（%塌陷）为54% +/-20%。年龄为24 - 31岁的男性（n = 12）的平均虚脱%为36% +/-19%，与之前报告的相似年龄男性的结果（35% +/- 18%）相当。男性与性别呈显著正相关（R-2 = 0.40，P
Background: A recent estimate for the normal range of forced expiratory tracheal collapse differs substantially from that in an earlier study performed with comparable measurement methods. Given differences in subject characteristics between the two samples, we hypothesized that these discrepant findings may reflect a heretofore unrecognized association between forced expiratory tracheal collapse and age or sex.Methods: We enrolled 40 female and 41 male healthy volunteers between 25 and 75 years of age who were without respiratory symptoms or known risk factors for tracheomalacia. Subjects underwent low-dose CT scanning at total lung capacity (TLC) and during forced exhalation (Expdyn) with spirometric monitoring and coaching. Percentage forced expiratory collapse was regressed on age for the total sample and separately within sex.Results: Mean tracheal cross-sectional area (CSA) was 2.54 cm(2) +/- 0.57 cm(2) at TLC and 1.15 cm(2) +/- 0.53 cm(2) at Expdyn. Mean percentage forced expiratory collapse (%collapse) was 54% +/- 20%. Men aged 24 to 31 years (n = 12) had mean %collapse of 36% +/- 19%, comparable to results previously reported for similarly aged men (35% +/- 18%). Men, but not women, showed a significant positive correlation (R-2 = 0.40, P