Diagnosis and Prognosis of Canine Cutaneous Mast Cell Tumors
Diagnosis and Prognosis of Canine Cutaneous Mast Cell Tumors
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DOI：
10.1016/j.cvsm.2019.04.002
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发表时间：
2019-09-01
影响因子：
1.9
通讯作者：
Camus, Melinda
中科院分区：
文献类型：
--
作者：
Kiupel, Matti;Camus, Melinda
犬皮肤肥大细胞瘤（MCT）是最常见的犬皮肤肿瘤之一，具有高度可变的生物学行为。本文详细介绍了目前的细胞学和组织学诊断和预后的方法，包括细胞学和组织学分级的优点和局限性，以及利用分子标记物，例如Ki 67，AgNORs，KIT表达和c-Kit突变，更准确地检测侵袭性MCT。此外，目前的方法来评估手术切缘和扩散到局部淋巴结进行了讨论。
Canine cutaneous mast cell tumors (MCTs) are among the most common canine cutaneous tumors, with highly variable biological behavior. This review describes in detail current approaches for cytologic and histologic diagnosis and prognosis, including advantages and limitations of cytologic and histologic grading and utilization of molecular markers, for example, Ki67, AgNORs, KIT expression, and c-Kit mutations, for a more accurate detection of aggressive MCTs. Furthermore, the current approach to evaluate surgical margins and spread to local lymph nodes is discussed.