Yersinia versus host immunity: how a pathogen evades or triggers a protective response.
Yersinia versus host immunity: how a pathogen evades or triggers a protective response.
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DOI：
10.1016/j.mib.2015.11.001
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发表时间：
2016-02
影响因子：
5.4
通讯作者：
Bliska JB
中科院分区：
文献类型：
--
作者：
Chung LK;Bliska JB
人类致病耶尔森氏菌引起的疾病是发病率和死亡率的重要来源。尽管如此，耶尔森氏菌致病和保护性宿主反应的具体机制仍然知之甚少。最近的研究表明，耶尔森氏菌扰乱细胞死亡途径，扰乱炎症过程，并利用免疫细胞促进疾病。耶尔森氏菌感染后的后续宿主反应包括协调先天和获得性免疫反应，试图控制细菌复制。在这里，我们重点介绍目前我们对致病耶尔森氏菌和宿主细胞之间的相互作用以及为对抗这些病原体而动员的保护性宿主反应的了解进展。总之，这些研究加强了我们对耶尔森氏菌发病机制的理解，并突出了宿主和微生物之间正在进行的斗争。
The human pathogenic Yersinia species cause diseases that represent a significant source of morbidity and mortality. Despite this, specific mechanisms underlying Yersinia pathogenesis and protective host responses remain poorly understood. Recent studies have shown that Yersinia disrupt cell death pathways, perturb inflammatory processes and exploit immune cells to promote disease. The ensuing host responses following Yersinia infection include coordination of innate and adaptive immune responses in an attempt to control bacterial replication. Here, we highlight current advances in our understanding of the interactions between the pathogenic yersiniae and host cells, as well as the protective host responses mobilized to counteract these pathogens. Together, these studies enhance our understanding of Yersinia pathogenesis and highlight the ongoing battle between host and microbe.