Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
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DOI：
10.3945/ajcn.2009.27725
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发表时间：
2010-03-01
影响因子：
7.1
通讯作者：
Krauss, Ronald M.
中科院分区：
文献类型：
--
作者：
Siri-Tarino, Patty W.;Sun, Qi;Krauss, Ronald M.
背景：人们普遍认为减少饮食中的饱和脂肪可以改善心血管健康。目的：本荟萃分析的目的是总结前瞻性流行病学研究中与膳食饱和脂肪与冠心病（CHD）、中风和心血管疾病（CVD； CHD包括中风）风险相关的证据。设计：通过检索MEDLINE和EMBASE数据库以及二级参考文献筛选出21项符合纳入本研究条件的研究。采用随机效应模型得出冠心病、中风和心血管疾病的综合相对风险估计值。结果：在随访的5-23年间，347,747例受试者中，11,006例发生冠心病或脑卒中。摄入饱和脂肪与冠心病、中风或心血管疾病的风险增加无关。与饱和脂肪摄入的极端分位数相比，冠心病的合并相对风险估计为1.07 (95% CI: 0.96, 1.19; P = 0.22)，中风的合并相对风险估计为0.81 (95% CI: 0.62, 1.05; P = 0.11)，心血管疾病的合并相对风险估计为1.00 （95% CI: 0.89, 1.11; P = 0.95）。考虑年龄、性别和研究质量并没有改变结果。结论：前瞻性流行病学研究的荟萃分析显示，没有明显证据表明膳食饱和脂肪与冠心病或心血管疾病风险增加有关。需要更多的数据来阐明心血管疾病风险是否可能受到用于替代饱和脂肪的特定营养素的影响。中华临床医学杂志，2010;31(1):535- 536。
Background: A reduction in dietary saturated fat has generally been thought to improve cardiovascular health.Objective: The objective of this meta-analysis was to summarize the evidence related to the association of dietary saturated fat with risk of coronary heart disease (CHD), stroke, and cardiovascular disease (CVD; CHD inclusive of stroke) in prospective epidemiologic studies.Design: Twenty-one studies identified by searching MEDLINE and EMBASE databases and secondary referencing qualified for inclusion in this study. A random-effects model was used to derive composite relative risk estimates for CHD, stroke, and CVD.Results: During 5-23 y of follow-up of 347,747 subjects, 11,006 developed CHD or stroke. Intake of saturated fat was not associated with an increased risk of CHD, stroke, or CVD. The pooled relative risk estimates that compared extreme quantiles of saturated fat intake were 1.07 (95% CI: 0.96, 1.19; P = 0.22) for CHD, 0.81 (95% CI: 0.62, 1.05; P = 0.11) for stroke, and 1.00 (95% CI: 0.89, 1.11; P = 0.95) for CVD.Consideration of age, sex, and study quality did not change the results. Conclusions: A meta-analysis of prospective epidemiologic studies showed that there is no significant evidence for concluding that dietary saturated fat is associated with an increased risk of CHD or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat. Am J Clin Nutr 2010;91:535-46.