Sensitivity to nikkomycin Z in Candida albicans: role of peptide permeases
Sensitivity to nikkomycin Z in Candida albicans: role of peptide permeases
复制标题
白色念珠菌对尼可霉素 Z 的敏感性：肽通透酶的作用
DOI：
10.1128/jb.160.3.884-888.1984
复制
发表时间：
1984
影响因子：
3.2
通讯作者：
LE Goffic
中科院分区：
文献类型：
--
作者：
J. Yadan;Martine Gonneau;Pierre Sarthou;Francois;LE Goffic
氚标记尼可霉素Z是几丁质合成酶的有效抑制剂，其摄取是由白念珠菌的肽转运系统介导的。放射性二肽和三肽的动力学运输试验和竞争研究表明，两个不同的系统在这种酵母中运行。尼可霉素Z通过这些系统之一转运，这是二肽和三肽的常见系统。基于对尼可霉素Z的抗性，分离到一个肽转运缺陷突变株。该突变体失去了大部分吸收二肽的能力，但同时增加了转运三肽的能力。这些结果表明C.白色念珠菌通过多种转运系统处理肽，并根据环境条件调节其表达。
The uptake of tritiated nikkomycin Z, a potent inhibitor of chitin synthetase, is mediated by a peptide transport system in Candida albicans. Kinetic transport assays with radioactive di- and tripeptides and competition studies suggest that two distinct systems operate in this yeast. Nikkomycin Z was transported through one of these systems, common to di- and tripeptides. A peptide transport-deficient mutant was isolated on the basis of its resistance to nikkomycin Z. The mutant lost most of its capacity to take up dipeptides but simultaneously increased its ability to transport tripeptides. These results indicate that C. albicans handles peptides through multiple transport systems and adjusts their expression to environmental conditions.
抗念珠菌剂的设计：多氧菌素L类似物的合成和生物学特性。
影响因子：
7.3
作者：
Shenbagamurthi,P;Smith,HA;Becker,JM;Steinfeld,A;Naider,F
通讯作者：
Naider,F