Influence of sample number and biopsy site on the histologic diagnosis of diffuse lung disease.
Influence of sample number and biopsy site on the histologic diagnosis of diffuse lung disease.
复制标题
样本数量和活检部位对弥漫性肺病组织学诊断的影响。
DOI：
10.1016/0003-4975(95)00895-0
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Lynch3rd,JP
中科院分区：
文献类型：
--
作者：
Flint,A;Martinez,FJ;Young,ML;Whyte,RI;Toews,GB;Lynch3rd,JP
尽管开放性活检被认为是获得肺组织用于诊断弥漫性浸润性肺部疾病的最佳方法，但关于活检部位的选择和组织样本的理想数量还没有普遍建立的指南。相对较少的调查一直致力于所施加的影响的部位和数量的活检标本上的组织学diagnosis. METHODS 77开放活检标本从不同的叶28例特发性肺纤维化进行了分析。组织病理学特征进行了半定量评价，每个样本的结果与其他样本从每个patient.STatistically的组织病理学特征之间没有观察到显着差异samples.CONCLUSIONSA单一慷慨（2厘米或更大的直径）的样本，从一个代表性的区域的X线摄影最涉及叶，将足以诊断和评估的目的。
BACKGROUNDAlthough open biopsy is considered the optimal method for obtaining lung tissue for the diagnosis of diffuse infiltrative pulmonary disorders, there are no universally established guidelines concerning biopsy site selection and the ideal number of tissue samples. Relatively few investigations have been devoted to the influence exerted by the site and number of biopsy samples on the histologic diagnosis.METHODSSeventy-seven open biopsy samples obtained from different lobes of 28 patients with idiopathic pulmonary fibrosis were analyzed. The histopathologic features were evaluated semiquantitatively and the results from each sample compared with those of the other samples obtained from each patient.RESULTSStatistically significant differences in histophatologic features were not observed between samples.CONCLUSIONSA single generous (2 cm or greater diameter) sample, obtained from a representative region of the radiographically most involved lobe, will suffice for diagnostic and evaluation purposes.