Communication Protocols Integrating Wearables, Ingestibles, and Implantables for Closed-Loop Therapies.
Communication Protocols Integrating Wearables, Ingestibles, and Implantables for Closed-Loop Therapies.
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DOI：
10.1016/j.device.2023.100092
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发表时间：
2023-09
期刊：
影响因子：
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通讯作者：
Ramy Ghanim;Anika Kaushik;Jihoon Park;A. Abramson
中科院分区：
文献类型：
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作者：
Ramy Ghanim;Anika Kaushik;Jihoon Park;A. Abramson
身体适形传感器和组织接口机器人治疗技术能够实时监测和治疗糖尿病、伤口愈合和其他危重情况。通过集成传感器和药物输送设备，科学家和工程师已经开发出具有按需治疗能力的闭环药物输送系统，以提供与目标发病率的化学、电气和物理信号相对应的及时治疗。为了在体内实现闭环功能，工程师们利用各种低功耗通信手段，将植入物的大小减少了数量级，将设备寿命从几个小时延长到几个月，并确保安全的高速数据传输。在这篇综述中，我们重点介绍了用于集成传感器和药物输送设备的通信协议，例如射频通信(例如，蓝牙、近场通信)、体内通信和超声波，使治疗结果得以改善。
Body-conformal sensors and tissue-interfacing robotic therapeutics enable the real-time monitoring and treatment of diabetes, wound healing, and other critical conditions. By integrating sensors and drug-delivery devices, scientists and engineers have developed closed-loop drug-delivery systems with on-demand therapeutic capabilities to provide just-in-time treatments that correspond to chemical, electrical, and physical signals of a target morbidity. To enable closed-loop functionalityin vivo, engineers utilize various low-power means of communication that reduce the size of implants by orders of magnitude, increase device lifetime from hours to months, and ensure the secure high-speed transfer of data. In this review, we highlight how communication protocols used to integrate sensors and drug-delivery devices, such as radio-frequency communication (e.g., Bluetooth, near-field communication), in-body communication, and ultrasound, enable improved treatment outcomes.