BMP-1 and the astacin family of metalloproteinases: a potential link between the extracellular matrix, growth factors and pattern formation.
BMP-1 and the astacin family of metalloproteinases: a potential link between the extracellular matrix, growth factors and pattern formation.
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DOI：
10.1002/bies.950180604
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发表时间：
1996-06
期刊：
影响因子：
--
通讯作者：
M. Sarras
中科院分区：
文献类型：
--
作者：
M. Sarras
金属蛋白酶的astacin家族的成员，如人骨形态发生蛋白1（BMP-1），以前已被链接到细胞分化和模式的形成在发展过程中，通过一个建议的作用，在激活潜在的生长因子的TGF-β超家族。最近的研究结果表明，BMP-1是相同的前胶原蛋白C-蛋白酶，这是一种金属蛋白酶参与细胞外基质（ECM）的形成。这一观察结果表明，在发育过程中，astacin金属蛋白酶，生长因子和细胞分化和模式形成之间可能存在功能联系。总之，目前的研究表明，BMP-1和其他可能的astacin金属蛋白酶是多功能的酶，直接作用于生长因子和ECM。这些双重作用结合起来，将对发展进程产生深远的影响。
Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP-1) have previously been linked to cell differentiation and pattern formation during development through a proposed role in the activation of latent growth factors of the TGF-beta superfamily. Recent findings indicate that BMP-1 is identical to pro-collagen C-proteinase, which is a metalloproteinase involved in extracellular matrix (ECM) formation. This observation suggests that a functional link may exist between astacin metalloproteinases, growth factors and cell differentiation and pattern formation during development. Taken together, current studies indicate that BMP-1 and possibly other astacin metalloproteinases are multifunctional enzymes that act directly on growth factors and the ECM. In combination, these dual actions would have profound effects on developmental processes.