Urolithin Metabotypes can Anticipate the Different Restoration of the Gut Microbiota and Anthropometric Profiles during the First Year Postpartum
Urolithin Metabotypes can Anticipate the Different Restoration of the Gut Microbiota and Anthropometric Profiles during the First Year Postpartum
复制标题
DOI：
10.3390/nu11092079
复制
发表时间：
2019-09-01
期刊：
影响因子：
5.9
通讯作者：
Victoria Selma, Maria
中科院分区：
文献类型：
--
作者：
Cortes-Martin, Adrian;Romo-Vaquero, Maria;Victoria Selma, Maria
肠道微生物群对饮食多酚鞣花单宁的代谢使人体尿素代谢类型分层，这取决于最终产生的尿素。代谢型- a只产生尿石素- a，代谢型- b除了尿石素- a还产生尿石素- b和异尿石素- a，代谢型- 0不产生尿石素。代谢型a被认为具有“保护性”，而代谢型b则容易导致心脏代谢障碍。我们分析了40名健康女性的肠道微生物组，确定了她们在产后3周、4、6和12个月的代谢型和肠道型，以及它们与人体测量学和肠道微生物变化的关系。代谢型a在体重减轻的母亲中占主导地位（75%），而代谢型b在体重减轻的母亲中占主导地位（54%）。分娩后，代谢a型母亲的微生物群发生了变化，而代谢b型母亲的微生物群在1年内几乎没有变化。代谢a型鉴别细菌与女性腰围的减少相关，而一些代谢b型细菌与体重指数（BMI）、腰围和腰臀比的减少呈负相关。与代谢型a相比，代谢型b与更稳健、更少调节的微生物和人体测量特征相关，其中代谢型a的这些特征在产后1年随访中正常化。因此，尿素代谢型评估可以作为一种工具，预测妇女在怀孕和分娩后显著改变的人体测量值和肠道微生物群的正常化倾向。
The metabolism of dietary polyphenols ellagitannins by the gut-microbiota allows the human stratification in urolithin metabotypes depending on the final urolithins produced. Metabotype-A only produces urolithin-A, metabotype-B yields urolithin-B and isourolithin-A in addition to urolithin-A, and metabotype 0 does not produce urolithins. Metabotype-A has been suggested to be 'protective', and metabotype-B dysbiotic-prone to cardiometabolic impairments. We analyzed the gut-microbiome of 40 healthy women and determined their metabotypes and enterotypes, and their associations with anthropometric and gut-microbial changes after 3 weeks, 4, 6, and 12 months postpartum. Metabotype-A was predominant in mothers who lost weight (>= 2 kg) (75%) versus metabotype-B (54%). After delivery, the microbiota of metabotype-A mothers changed, unlike metabotype-B, which barely changed over 1 year. The metabotype-A discriminating bacteria correlated to the decrease of the women's waist while some metabotype-B bacteria were inversely associated with a reduction of body mass index (BMI), waist, and waist-to-hip ratio. Metabotype-B was associated with a more robust and less modulating microbial and anthropometric profiles versus metabotype-A, in which these profiles were normalized through the 1-year follow-up postpartum. Consequently, urolithin metabotypes assessment could be a tool to anticipate the predisposition of women to normalize their anthropometric values and gut-microbiota, significantly altered during pregnancy and after childbirth.