CELLULAR MOSAICISM IN THE METHYLATION AND EXPRESSION OF HEMIZYGOUS LOCI IN THE MOUSE
CELLULAR MOSAICISM IN THE METHYLATION AND EXPRESSION OF HEMIZYGOUS LOCI IN THE MOUSE
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DOI：
10.1101/gad.3.11.1669
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发表时间：
1989-11-01
影响因子：
10.5
通讯作者：
SAPIENZA, C
中科院分区：
文献类型：
--
作者：
MCGOWAN, R;CAMPBELL, R;SAPIENZA, C
提出的体细胞中位点特异性甲基化表型遗传模型包括那些甲基化模式的稳定遗传，使得所有细胞都含有类似的甲基化位点，以及甲基化遗传可以是可变的模型。我们通过检测小鼠半合子位点的甲基化和表达来研究这些可能性。我们的研究结果表明，甲基化和表达的差异可以存在于表面上相同的细胞之间，这种嵌合是遗传控制的。
Proposed models for the inheritance of locus-specific methylation phenotypes in somatic cells include those in which there is stable inheritance of a methylation pattern such that all cells contain a similarly methylated locus, as well as models in which the inheritance of methylation can be variable. We investigated these possibilities by examining the methylation and expression of hemizygous loci in the mouse. Our results demonstrate that differences in both methylation and expression can exist between apparently identical cells and that such mosaicism is genetically controlled.