The effects of growth factors on skeletal muscle lesions.
The effects of growth factors on skeletal muscle lesions.
复制标题
生长因子对骨骼肌损伤的影响。
作者：
A. Gigante;M. Cianforlini;S. Manzotti;S. Ulisse
骨骼肌损伤是导致严重长期疼痛和身体残疾的常见原因，占所有运动损伤的55%。直接或间接肌肉损伤后愈合过程的各个阶段是复杂但明确定义的过程，包括协调良好的步骤：变性、炎症、再生和纤维化。尽管这种情况经常发生，并存在大量关于肌肉损伤的病理生理学数据，但在严格控制的试验中，迄今所采用的治疗策略没有一种被证明是真正有效的。目前大多数肌肉损伤的治疗都是基于有限的实验和临床数据，和/或只进行了经验测试。富含血小板血浆(PRP)是一种基于自体生长因子(GFS)促进组织愈合、促进肌肉再生、增加新生血管和减少纤维化、使肌肉损伤后快速恢复的有前景的替代方法。因此，还需要进一步的实验研究，包括对PRP释放的特定GFs的量化，以及关于血管生成、肌肉生成和功能恢复的额外数据，以最终验证PRP在肌肉病变治疗中的有效性假说，并为其广泛的临床应用开辟道路。
Skeletal muscle injuries are common causes of severe long-term pain and physical disability, accounting for up to 55% of all sports injuries. The phases of the healing process after direct or indirect muscle injury are complex but clearly defined processes comprising well-coordinated steps: degeneration, inflammation, regeneration, and fibrosis. Despite this frequent occurrence and the presence of a body of data on the pathophysiology of muscle injuries, none of the treatment strategies adopted to date have been shown to be really effective in strictly controlled trials. Most current muscle injury treatments are based on limited experimental and clinical data and/or were only empirically tested. Platelet-rich plasma (PRP) is a promising alternative approach based on the ability of autologous growth factors (GFs) to accelerate tissue healing, improve muscular regeneration, increase neovascularization and reduce fibrosis, allowing rapid recovery after muscle lesions. Thus, further experimental studies that include the quantification of specific GFs released by PRP, as well as additional data on angiogenesis, myogenesis and functional recovery are needed to ultimately validate the hypothesis of PRP efficacy in the treatment of muscle lesions and open the way for its wide clinical application.