INTRAVENOUS SELF-INJECTION OF METHCATHINONE IN THE BABOON
INTRAVENOUS SELF-INJECTION OF METHCATHINONE IN THE BABOON
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DOI：
10.1016/0091-3057(94)90307-7
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发表时间：
1994-04-01
影响因子：
3.6
通讯作者：
GRIFFITHS, RR
中科院分区：
文献类型：
--
作者：
KAMINSKI, BJ;GRIFFITHS, RR
甲卡西酮是一种苯基异丙胺，由秘密实验室生产，并在非法毒品贩运中查明。本研究评估了三狒狒使用可卡因替代程序静脉注射甲卡西酮的自我管理。根据固定比例（FR）计划，每天24小时进行静脉自注射，每次注射后暂停3小时。用盐酸外消旋甲基卡西酮（0.01-1.0 mg/kg/注射）及其代药剂代替可卡因15天或更长时间。食物颗粒递送的同步FR时间表允许评估食物摄入的任何变化。甲卡西酮自注射呈剂量依赖性。低剂量的甲卡西酮（0.01和0.032）分别维持了低和中等的自我注射率，而高剂量（0.1、0.32和1.0）维持了高于载体对照的自注射率，与可卡因的自注射率相当。急性给药3.2 mg/kg给两只狒狒产生精神运动兴奋剂毒性的迹象。没有观察到食物摄入的系统性变化。目前的数据表明，甲基卡西酮在狒狒中起着正强化作用，表明甲基卡西酮可能有滥用的潜力。
Methcathinone is a phenylisopropylamine that has been produced by clandestine laboratories and identified in illicit drug traffic. The present study evaluated the intravenous self-administration of methcathinone in three baboons using a cocaine substitution procedure. Intravenous self-injections were available 24 h/ day according to a fixed-ratio (FR) schedule with a 3-h timeout following each injection. Doses of racemic methcathinone HCl (0.01-1.0 mg/kg/injection) and its vehicle were substituted for cocaine for 15 or more days. A concurrent FR schedule of food pellet delivery allowed evaluation of any changes in food intake. Self-injection of methcathinone was dose dependent. The lower doses of methcathinone, 0.01 and 0.032, maintained low and intermediate rates of self-injection, respectively, while the higher doses, 0.1, 0.32, and 1.0, maintained rates above vehicle control and comparable to those maintained by cocaine. Acute administration of 3.2 mg/kg to two baboons produced signs of psychomotor stimulant toxicity. Systematic changes in food intake were not observed. The present data indicate that methcathinone functions as a positive reinforcer in baboons and suggests that methcathinone may have abuse potential.