Expression of survivin and p53 in oral lichen planus, lichenoid reaction and lichenoid dysplasia: An immunohistochemical study.
Expression of survivin and p53 in oral lichen planus, lichenoid reaction and lichenoid dysplasia: An immunohistochemical study.
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DOI：
10.4103/jomfp.jomfp_39_15
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发表时间：
2017-09-01
期刊：
影响因子：
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通讯作者：
Varekar, Aniruddha
中科院分区：
文献类型：
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作者：
Basheer, Shaini;Shameena, P M;Varekar, Aniruddha
目的：比较口腔扁平苔藓(OLP)、口腔扁平苔藓(OLR)和口腔苔藓样异型增生(OLD)中与细胞凋亡和抑癌基因进程相关的蛋白的表达。材料和方法：采用免疫组织化学方法检测Survivin和P53在30例口腔扁平苔藓、OLR和OLD中的表达。结果：P53蛋白在老年组7例(70%)、口腔扁平苔藓4例(40%)、口腔扁平苔藓2例(20%)及正常口腔黏膜无表达。不同实体间P53平均表达差异有统计学意义(P=0.01)。Survivin在老年组(50%)、扁平苔藓组(10%)、扁平苔藓组(0%)和正常黏膜组(0%)中的阳性表达率差异有统计学意义(P=0.004)。P53和Survivin在OLP和OLD中的表达呈正相关。结论：苔藓样异型增生中P53和Survivin的表达范围不是OLP，而是白斑。另一方面，OLR似乎是一种无害的损害。对口腔扁平苔藓的研究结果不是决定性的，但指向口腔扁平苔藓中一种微小但重要的恶性潜能。这种比较研究强调了对口腔扁平苔藓和相关病变进行活检对正确诊断和适当处理的重要性。
CONTEXT: The malignant transformation potential of oral lichen planus (OLP) and related lesions is a subject of great controversy.AIM: The aim of this study was to compare the expression of proteins related to apoptosis and tumour suppressor gene processes in OLP, oral lichenoid reaction (OLR) and oral lichenoid dysplasia (OLD).MATERIALS AND METHODS: The immunohistochemical study was carried out to investigate the expressions of survivin and p53 in a total of 30 lesional biopsy specimens - 10 cases each of OLP, OLR and OLD. The expression rates were further compared with 10 control specimens of normal oral mucosa (NORM).RESULTS: Immunoreactivity for p53 was seen in 7 cases (70%) of OLD, 4 cases (40%) of OLP and 2 cases (20%) of OLR and none of NORM. We obtained a significant difference (P = 0.01) in mean p53 expression between the different entities. The positive staining rate of survivin was found to be significantly different between OLD (50%), OLP (10%), OLR (0%), and normal mucosa (0%) (P = 0.004). There was a positive correlation between p53 and survivin expression in OLP and OLD using Pearson's correlation coefficient.CONCLUSION: Lichenoid dysplasia has shown p53 and survivin expression in the range of not OLP, but leukoplakia. On the other hand, OLR seems to be an innocuous lesion. The study results with OLP are inconclusive but points toward a small but important malignant potential in OLP. This kind of comparative study highlights the importance of biopsying OLP and related lesions for proper diagnosis and appropriate management.