Challenges and Opportunities in Linking Long Noncoding RNAs to Cardiovascular, Lung, and Blood Diseases.
Challenges and Opportunities in Linking Long Noncoding RNAs to Cardiovascular, Lung, and Blood Diseases.
复制标题
将长期非编码RNA与心血管，肺和血液疾病联系起来的挑战和机遇。
DOI：
10.1161/atvbaha.116.308513
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
National Heart, Lung, and Blood Institute Workshop Participants*
中科院分区：
文献类型：
--
作者：
Freedman JE;Miano JM;National Heart, Lung, and Blood Institute Workshop Participants*
The new millennium heralds an unanticipated surge of genomic information, most notably an expansive class of long noncoding RNAs. These transcripts, which now outnumber all protein-coding genes, often exhibit the same characteristics as mRNAs (RNA polymerase II-dependent, 5’ methyl capped, multi-exonic, polyadenylated), yet they do not encode for stable, well-conserved proteins. Elucidating the function of all relevant lncRNAs in heart, vasculature, lung, and blood is essential for generating a complete interactome in these tissues. This is particularly evident as an increasing number of investigators perform RNA-sequencing experiments where, typically, annotated lncRNAs exhibit impressive changes in gene expression. How does one go about evaluating an lncRNA when the sequence of the transcript lends no insight into how it may function within a cell type? Here, we provide a brief overview for the rational study of long noncoding RNAs.
