Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial
Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial
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DOI：
10.1016/s0140-6736(97)09214-3
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发表时间：
1998-03-07
期刊：
影响因子：
168.9
通讯作者：
Wheatley, K
中科院分区：
文献类型：
--
作者：
Burnett, AK;Goldstone, AH;Wheatley, K
背景：在首次缓解的急性髓系白血病患者中，有三种策略用于预防复发。大多数有合适捐赠者的人都接受了异基因造血干细胞移植。其他患者可接受强化化疗或自体移植；我们进行了这项随机前瞻性试验，以评估哪个是更好的选择。
Background Three strategies are used to prevent relapse in patients with acute myeloid leukaemia in first remission. Most of those with suitable donors are offered allogeneic haemopoietic-stem-cell transplant. Other patients may receive intensive chemotherapy or autologous transplantation; we undertook this randomised prospective trial to assess which is the better option.Methods After three courses of intensive chemotherapy, bone marrow was harvested from patients (