Association between interleukin 17/interleukin 17 receptor gene polymorphisms and papillary thyroid cancer in Korean population
Association between interleukin 17/interleukin 17 receptor gene polymorphisms and papillary thyroid cancer in Korean population
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DOI：
10.1016/j.cyto.2014.11.011
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发表时间：
2015-02-01
期刊：
影响因子：
3.8
通讯作者：
Eun, Young Gyu
中科院分区：
文献类型：
--
作者：
Lee, Young Chan;Chung, Joo-Ho;Eun, Young Gyu
背景：尽管最近的许多研究都暗示了白细胞介素17（IL17）在肿瘤发展中的作用，但IL17参与的机制仍然不明确。本研究的目的是确定IL17和IL17R的单核苷酸多态性（snp）是否有助于甲状腺乳头状癌（FTC）的发展，并评估IL17和IL17R snp与PTC临床病理特征之间的关系。材料和方法：采用直接测序方法对94例PTC患者和260例非FTC患者（对照组）的IL17A、IL17RA和IL17RB基因内的8个snp进行基因分型。基因数据分析使用市售软件。然后进行统计分析以检验这些snp与PTC临床病理特征之间的关系。结果：基因分型分析显示，IL17RA SNP rs4819554（共显性模型1，优势比(OR) = 0.39, P = 0.001）和IL17RB SNP rs1025689（显性模型，OR = 0.59, P = 0.043）与Pit缺失显著相关。有趣的是，IL17A。SNP rs2275913（共显性模型2，OR = 0.19, P = 0.034）与多焦点缺失显著相关。此外，IL17RA SNP rs4819554（优势模型，OR = 0.25, P = 0.010）与癌症双侧性缺失显著相关。结论：通过对FTC患者IL17和IL17R基因snp的研究，我们证明了IL17RA多态性可以影响Pit的发展和双侧性。(C) 2014 Elsevier Ltd.版权所有。
Background: Although numerous recent studies have implicated a role for interleukin 17(IL17) in tumor development, the mechanisms of IL17 involvement are still uncharacterized. The aims of this study were to determine whether single nucleotide polymorphisms (SNPs) in IL17 and IL17R contribute to the development of papillary thyroid cancer (FTC) and to assess the relationship between IL17 and IL17R SNPs and the clinicopathologic characteristics of PTC.Materials and methods: Eight SNPs located within the IL17A, IL17RA, and IL17RB genes were genotyped using direct sequencing in 94 patients with PTC and 260 patients without FTC (controls). Genetic data were analyzed using commercially available software. Statistical analyses were then performed to examine the relationships between these SNPs and the clinicopathologic characteristics of PTC.Results: Genotyping analysis demonstrated that the IL17RA SNP rs4819554 (codominant model 1, odds ratio (OR) = 0.39, P = 0.001) and the IL17RB SNP rs1025689 (dominant model, OR = 0.59, P = 0.043) were significantly associated with lack of Pit. Interestingly, the IL17A.SNP rs2275913 (codominant model 2, OR = 0.19, P = 0.034) was significantly associated with lack of multifocality. Furthermore, the IL17RA SNP rs4819554 (dominant model, OR = 0.25, P = 0.010) was significantly associated with lack of cancer bilaterality.Conclusion: In this study of SNPs in the IL17 and IL17R genes in patients with FTC, we demonstrated that IL17RA polymorphisms can influence both the development and the bilaterality of Pit. (C) 2014 Elsevier Ltd. All rights reserved.