An Updating Meta-Analysis of the GSTM1, GSTT1, and GSTP1 Polymorphisms and Prostate Cancer: A HuGE Review
An Updating Meta-Analysis of the GSTM1, GSTT1, and GSTP1 Polymorphisms and Prostate Cancer: A HuGE Review
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DOI：
10.1002/pros.20907
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发表时间：
2009-05-01
期刊：
影响因子：
2.8
通讯作者：
Jian, Lijuan
中科院分区：
文献类型：
--
作者：
Mo, Zengnan;Gao, Yong;Jian, Lijuan
据推测，GSTM1、GSTT1缺乏和GSTP1 （105Ile/Val转换）的个体对致癌物的易感性增加，更容易患前列腺癌。近年来，GST状态作为前列腺癌的危险因素被广泛研究；然而，结果是不一致的。为了重新审视这一争议，我们对29项GSTM1基因分型研究（4564例前列腺癌病例和5464例对照）、22项GSTT1基因分型研究（3837例和4552例对照）和24项GSTP1基因分型研究（5301例和5621例对照）进行了更新的荟萃分析。随机效应优势比为1.33[95%置信区间（95% CI）： 1.15, 1.55；GSTT1基因型与GSTP1-Val基因型与GSTP1-Ile基因型的差异分别为1.05 （95% CI: 0.86, 1.27; I-2 = 68.2%， P异质性= 0.00）和1.06 （95% CI: 0.91, 1.24; I-2 = 71.5%， P异质性= 0.00）。对于GSTM1多态性，白种人和亚洲人得到了相似的结果，非洲人除外。GSTT1或GSTP1多态性与前列腺癌风险在不同种族间无相关性。总之，本研究的主要发现表明，GSTM1多态性在广泛的人群基础上增加了前列腺癌的风险，然而，没有发现GSTT1和GSTP1状态与前列腺癌风险之间的关系。《中华医学会杂志》，2009。(C) 2009 Wiley-Liss, Inc。
It has been postulated that individuals with GSTM1, GSTT1 deficiency and, GSTP1 (105Ile/Val transition) have increased susceptibility to carcinogens and are more likely to develop prostate cancer. In recent years, GST status has been extensively studied as a prostate cancer risk factor; however, the results are inconsistent. To re-examine this controversy, we have undertaken an updating meta-analysis of 29 studies with GSTM1 genotyping (4,564 prostate cancer cases and 5,464 controls), 22 studies with GSTT1 genotyping (3,837 cases and 4,552 controls), and 24 studies with GSTP1 genotyping (5,301 cases and 5,621 controls). The random effects odds ratio was 1.33 [95% confidence interval (95% CI): 1.15, 1.55; I-2 = 68.9%, P for heterogeneity = 0.00] for the GSTM1 null versus present genotype and 1.05 (95% CI: 0.86, 1.27; I-2 = 68.2%, P for heterogeneity = 0.00) for the GSTT1 null versus present genotype, and 1.06 (95% CI: 0.91, 1.24; I-2 = 71.5%, P for heterogeneity = 0.00) for the GSTP1-Val versus GSTP1-Ile allele. For GSTM1 polymorphism, similar results reached in Caucasians and Asians, with exception for Africans. No association between GSTT1 or GSTP1 polymorphisms and prostate cancer risk was detected in different racial. In conclusion, the major finding of our study suggested that GSTM1 polymorphism conferred an increasing risk of prostate cancer on a wide population basis, however, no relationship was found between GSTT1 and GSTP1 status and the risk of prostate cancer. Prostate 69: 662-688, 2009. (C) 2009 Wiley-Liss, Inc.