Microvascular disease and cardiovascular outcomes among individuals with type 2 diabetes.
Microvascular disease and cardiovascular outcomes among individuals with type 2 diabetes.
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2型糖尿病患者的微血管疾病和心血管结局
DOI：
10.1016/j.diabres.2021.108859
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发表时间：
2021-06
影响因子：
5.1
通讯作者：
Echouffo-Tcheugui JB
中科院分区：
文献类型：
--
作者：
Kaze AD;Santhanam P;Erqou S;Bertoni AG;Ahima RS;Echouffo-Tcheugui JB
评估2型糖尿病患者微血管疾病（MVD）与心血管疾病（CVD）的关系。在前瞻性（糖尿病健康行动）研究中，共有4098名无心血管疾病的2型糖尿病患者接受了MVD（糖尿病肾病、视网膜病变或神经病变）评估。Cox模型用于生成以下风险比（hr）：(1) CVD复合（心肌梗死、卒中、因心绞痛住院和/或心血管原因死亡）、(2)冠状动脉疾病（CAD）、(3)卒中和(4)CVD相关死亡。在4098名参与者中，34.7% （n = 1424）在基线时患有MVD。在平均9.5年的时间里，487人发生心血管疾病，410人发生冠心病，100人中风，54人死于心血管疾病。在校正相关混杂因素后，MVD与CVD复合（HR 1.34, 95% CI 1.11-1.61）、CAD （HR 1.24, 95% CI 1.01-1.52）、卒中（HR 1.55, 95% CI 1.03-2.33）和心血管死亡率（HR 1.26, 95% CI 0.72-2.22）的风险增加相关。糖尿病肾病、视网膜病变和神经病变的复合心血管疾病的hr分别为1.11 （95% CI 0.89-1.38）、1.63 （95% CI 1.22-2.17）和1.16 （95% CI 0.92-1.46）。我们的研究结果强调了MVD在2型糖尿病CVD风险评估中的相关性。
To evaluate the associations of microvascular disease (MVD) with incident cardiovascular disease (CVD) in individuals with type 2 diabetes. A total of 4098 participants with type 2 diabetes and without CVD were assessed for MVD (diabetic kidney disease, retinopathy or neuropathy) in the Look AHEAD (Action for Health in Diabetes) study. Cox models were used to generate hazard ratios (HRs) for: (1) CVD composite (myocardial infarction, stroke, hospitalization for angina and/or death from cardiovascular causes), (2) coronary artery disease (CAD), (3) stroke, and (4) CVD-related deaths. Of 4098 participants, 34.7% (n = 1424) had MVD at baseline. Over a median of 9.5 years, 487 developed the CVD composite, 410 CAD events, 100 stroke, and 54 CVD-related deaths. After adjusting for relevant confounders, MVD was associated with increased risks of CVD composite (HR 1.34, 95% CI 1.11–1.61), CAD (HR 1.24, 95% CI 1.01–1.52), stroke (HR 1.55, 95% CI 1.03–2.33), and cardiovascular mortality (HR 1.26, 95% CI 0.72–2.22). HRs for CVD composite by type of MVD were 1.11 (95% CI 0.89–1.38), 1.63 (95% CI 1.22–2.17) and 1.16 (95% CI 0.92–1.46) for diabetic kidney disease, retinopathy, and neuropathy, respectively. Our findings underscore the relevance of MVD in CVD risk assessment in type 2 diabetes.
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影响因子：
3.5
作者：
Tong, P. C. Y.;Kong, A. P.;Cockram, C. S.
通讯作者：
Cockram, C. S.
影响因子：
8.2
作者：
Bruno, G.;Merletti, F.;Cavallo-Perin, P.
通讯作者：
Cavallo-Perin, P.
影响因子：
8.3
作者：
Kothari, V;Stevens, RJ;Holman, RR
通讯作者：
Holman, RR
影响因子：
39.2
作者：
Levey AS;Stevens LA;Schmid CH;Zhang YL;Castro AF 3rd;Feldman HI;Kusek JW;Eggers P;Van Lente F;Greene T;Coresh J;CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
通讯作者：
CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
影响因子：
3.5
作者：
Yokoyama, H.;Oishi, M.;Sone, H.
通讯作者：
Sone, H.