Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation
Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation
复制标题
DOI：
10.1016/s1471-4906(01)01863-4
复制
发表时间：
2001-04-01
影响因子：
16.8
通讯作者：
Salmon, M
中科院分区：
文献类型：
--
作者：
Buckley, CD;Pilling, D;Salmon, M
成纤维细胞是免疫系统中重要的前哨细胞，在此，提出这些细胞在从急性炎症到适应性免疫和组织修复的转变中起关键作用。这表明，慢性炎症的发生是由于成纤维细胞行为紊乱，其中未能关闭其炎症程序导致炎症组织内白细胞的不适当存活和保留。
Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that these cells play a critical role in the switch from acute inflammation to adaptive immunity and tissue repair. It is suggested that chronic inflammation occurs because of disordered fibroblast behaviour in which failure to switch off their inflammatory programme leads to the inappropriate survival and retention of leukocytes within inflamed tissue.