Establishment of a new human uterine cervical adenocarcinoma cell-line, siso, and its reactivity to anticancer reagents.
Establishment of a new human uterine cervical adenocarcinoma cell-line, siso, and its reactivity to anticancer reagents.
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新人宫颈腺癌细胞株siso的建立及其抗癌试剂的反应性。
DOI：
10.3892/ijo.6.5.1099
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发表时间：
1995
影响因子：
5.2
通讯作者：
Takeshi Watanabe
中科院分区：
文献类型：
--
作者：
K. Sonoda;Manabu Nakashima;Toshiaki Saito;S. Amada;T. Kamura;H. Nakano;Takeshi Watanabe
从患有子宫颈腺癌的患者建立人细胞系SiSo。SiSo细胞表达MHC I类抗原、各种粘附分子和肿瘤相关抗原如CA 125、CEA和GA 733。抗肿瘤药物可明显抑制CA125抗原的分泌。然而，它们的生长不受任何测试的抗癌试剂的影响，这表明在用抗癌试剂处理后肿瘤生长的抑制和肿瘤相关抗原的分泌的抑制之间存在差异。SiSo细胞系将为子宫腺癌的研究提供工具。
A human cell line, SiSo, was established from a patient afflicted with uterine cervical adenocarcinoma. The SiSo cell expresses MHC class I antigen, various kinds of adhesion molecules and tumor-associated antigens such as CA125, CEA and GA733. The secretion of CA125 antigen was markedly suppressed by anti-cancer reagents. However, their growth was not affected by any of the anti-cancer reagents tested, suggesting a discrepancy between inhibition of tumor growth and suppression of secretion of tumor-associated antigens after treatment with anti-cancer reagents. The SiSo cell line will provide a tool for investigation of uterine adenocarcinoma.