Tuning of ventral tenia tecta neurons of the olfactory cortex to distinct scenes of feeding behavior
Tuning of ventral tenia tecta neurons of the olfactory cortex to distinct scenes of feeding behavior
复制标题
嗅觉皮层腹侧顶盖神经元的调节以适应不同的进食行为场景
DOI：
10.1101/455089
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Kensaku Mori
中科院分区：
文献类型：
--
作者：
Kazuki Shiotani;Hiroyuki Manabe;Yuta Tanisumi;Koshi Murata;Junya Hirokawa;Yoshio Sakurai;Kensaku Mori
嗅带（vTT）是嗅觉皮层的一部分，它接收来自嗅球的嗅觉信号和来自前额叶皮层的自上而下的信号。为了解决vTT的神经元活动是否以及如何受到前额叶认知过程（如目标导向行为期间发生的注意力、期望和工作记忆）的调节的问题，我们记录了自由移动的清醒小鼠的vTT中的个体神经元反应，这些小鼠进行了学习气味导向的进食和饮水行为。我们发现，单个vTT细胞的放电模式具有可重复的行为相关性，因此小鼠在学习行为期间遇到的环境和行为场景是单个vTT神经元何时最大程度放电的主要决定因素。此外，这些场景细胞的尖峰活动不仅受到当前场景的调制，而且还受到老鼠预测的未来场景的调制。我们发现vTT接受来自嗅球的传入信息以及来自内侧前额叶皮层和梨状皮层的自上而下的输入，这些结果表明，在不同的场景中，不同的vTT细胞群被激活，并表明在不同的场景中，嗅觉感觉信息的加工是由不同的场景细胞处理的。换句话说，在进食和饮水行为期间，vTT通过选择性地偏置特定场景单元而根据场景变化雅阁随时改变其工作模式。vTT中嗅觉感觉加工的场景效应对嗅觉记忆的自上而下注意和场景依赖性编码和回忆的神经回路机制具有启示意义。
Ventral tenia tecta (vTT) is a part of the olfactory cortex that receives both olfactory sensory signals from the olfactory bulb and top-down signals from the prefrontal cortex. To address the question whether and how the neuronal activity of the vTT is modulated by prefrontal cognitive processes such as attention, expectation and working memory that occurs during goal-directed behaviors, we recorded individual neuronal responses in the vTT of freely moving awake mice that performed learned odor-guided feeding and drinking behaviors. We found that the firing pattern of individual vTT cells had repeatable behavioral correlates such that the environmental and behavioral scene the mouse encountered during the learned behavior was the major determinant of when individual vTT neurons fired maximally. Furthermore, spiking activity of these scene cells was modulated not only by the present scene but also by the future scene that the mouse predicted. We show that vTT receives afferent input from the olfactory bulb and top-down inputs from the medial prefrontal cortex and piriform cortex.These results indicate that different groups of vTT cells are activated at different scenes and suggest that processing of olfactory sensory information is handled by different scene cells during distinct scenes of learned feeding and drinking behaviors. In other words, during the feeding and drinking behavior, vTT changes its working mode moment by moment in accord with the scene change by selectively biasing specific scene cells. The scene effect on olfactory sensory processing in the vTT has implications for the neuronal circuit mechanisms of top-down attention and scene-dependent encoding and recall of olfactory memory.