Recreational Cannabis Legalization and Opioid-Related Deaths in Colorado, 2000-2015
Recreational Cannabis Legalization and Opioid-Related Deaths in Colorado, 2000-2015
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DOI：
10.2105/ajph.2017.304059
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发表时间：
2017-11-01
影响因子：
12.7
通讯作者：
Wagenaar, Alexander C.
中科院分区：
文献类型：
--
作者：
Livingston, Melvin D.;Barnett, Tracey E.;Wagenaar, Alexander C.
目标.研究科罗拉多娱乐性大麻使用合法化与阿片类药物相关死亡之间的关联。我们使用中断时间序列设计（2000-2015）来比较科罗拉多商店开始销售娱乐性大麻之前和之后每月阿片类药物相关死亡的水平和斜率变化。我们还通过比较随访结束时未调整的模型平滑死亡人数与合法化之前的死亡人数来描述阿片类药物相关死亡的百分比变化。科罗拉多娱乐性大麻销售和使用合法化导致阿片类药物相关死亡每月减少0.7例（B = -0.68; 95%置信区间=-1.34，-0.03）。这一减少代表了科罗拉多州阿片类药物相关死亡上升趋势的逆转。科罗拉多大麻合法化与阿片类药物相关死亡的短期减少有关。随着更多的数据变得可用，研究应该复制这些分析在其他国家与法律的娱乐大麻。
Objectives. To examine the association between Colorado's legalization of recreational cannabis use and opioid-related deaths.Methods. We used an interrupted time-series design (2000-2015) to compare changes in level and slope of monthly opioid-related deaths before and after Colorado stores began selling recreational cannabis. We also describe the percent change in opioid-related deaths by comparing the unadjusted model-smoothed number of deaths at the end of follow-up with the number of deaths just prior to legalization.Results. Colorado's legalization of recreational cannabis sales and use resulted in a 0.7 deaths per month (b = -0.68; 95% confidence interval = -1.34, -0.03) reduction in opioid-related deaths. This reduction represents a reversal of the upward trend in opioid-related deaths in Colorado.Conclusions. Legalization of cannabis in Colorado was associated with short-term reductions in opioid-related deaths. As additional data become available, research should replicate these analyses in other states with legal recreational cannabis.