How to open a proton pore-more than S4?
How to open a proton pore-more than S4?
复制标题
如何开启质子孔——S4以上？
DOI：
10.1038/nsmb.2997
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发表时间：
2015
影响因子：
16.8
通讯作者：
Chanda,Baron
中科院分区：
文献类型：
--
作者：
Goldschen-Ohm,MarcelP;Chanda,Baron
Pioneering studies in voltage-gated potassium channels have described movement of the voltage-sensing domain (VSD) S4 helix across the membrane electric field in molecular detail, but much less is known regarding opening of the intrinsic proton pore within VSDs of voltage-dependent proton channels. By systematically probing local kinematics, a new study reveals that movements in helix S1 correlate with pore opening and are distinct from voltage-sensing movements of the charged S4 segment.
