Homocysteine is lower in the third trimester of pregnancy in women with enhanced folate status from continued folic acid supplementation
Homocysteine is lower in the third trimester of pregnancy in women with enhanced folate status from continued folic acid supplementation
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DOI：
10.1373/clinchem.2004.032698
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发表时间：
2005-03-01
影响因子：
9.3
通讯作者：
McNulty, H
中科院分区：
文献类型：
--
作者：
Holmes, VA;Wallace, JMW;McNulty, H
背景：在许多国家，当前建议女性从受孕前直至妊娠第 12 周结束时每天补充 400 杯叶酸，以预防神经管缺陷。低叶酸状态与血浆总同型半胱氨酸 (tHcy) 浓度升高相关，而血浆总同型半胱氨酸 (tHcy) 是与先兆子痫等妊娠并发症相关的危险因素。方法：在一项纵向研究中，我们测定了 101 名妊娠 12、20 和 35 周的孕妇、同时采样的 35 名非妊娠对照者和亚组（n = 21 名孕妇和 19 名非妊娠对照者）的 tHcy 和相应的叶酸状态。结果：与非妊娠对照相比，整个妊娠期间血浆 tHcy 显着降低，妊娠中期的值最低，妊娠晚期则增加至非妊娠值。重要的是，服用叶酸补充剂的孕妇的平均 tHcy 浓度低于未补充叶酸的孕妇，这一效应在妊娠晚期达到显着水平（5.45 与 7.40 mumol/L；P
Background: In many countries, current recommendations are that women take a daily 400-mug folic acid supplement from before conception until the end of the 12th week of gestation for the prevention of neural tube defects. Low folate status is associated with an increased concentration of plasma total homocysteine (tHcy), a risk factor associated with pregnancy complications such as preeclampsia.Methods: In a longitudinal study, we determined tHcy and corresponding folate status in 101 pregnant women at 12, 20, and 35 weeks of gestation, in 35 nonpregnant controls sampled concurrently, and in a subgroup (n = 21 pregnant women and 19 nonpregnant controls) at 3 days postpartum.Results: Plasma tHcy was significantly lower throughout pregnancy compared with nonpregnant controls, with values lowest in the second trimester before increasing toward nonpregnant values in the third trimester. Importantly, mean tHcy concentrations were lower in pregnant women taking folic acid supplements than in those not, an effect that reached significance in the third trimester (5.45 vs 7.40 mumol/L; P