The influence of early life sexual abuse on oxytocin concentrations and premenstrual symptomatology in women with a menstrually related mood disorder.
The influence of early life sexual abuse on oxytocin concentrations and premenstrual symptomatology in women with a menstrually related mood disorder.
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DOI：
10.1016/j.biopsycho.2015.04.003
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发表时间：
2015-07
影响因子：
2.6
通讯作者：
Girdler SS
中科院分区：
文献类型：
--
作者：
Crowley SK;Pedersen CA;Leserman J;Girdler SS
催产素（OT），与联系和社会纽带，社会显着性，和压力/疼痛调节，可能发挥作用的病理生理学的压力相关的障碍，包括精神相关的情绪障碍（MRMD）。早期生活性虐待（ESA）对成人依恋、情感调节和疼痛敏感性的不良影响表明，在MRMD病理生理学中存在ESA相关的OT失调。我们研究了ESA对血浆OT的影响，以及OT与MRMD临床现象学的关系。与没有ESA的MRMD女性（n=40）相比，ESA女性（n=20）显示出显著更高的OT [5.39 pg/mL（SD，2.4）vs. 4.36 pg/mL（SD，1.1）; t（58）=-2.26，p =.03]。在患有ESA的女性中，OT与经前心理和躯体症状显著负相关（r =-0.45至-0.64，p <0.05）。OT和经前月经失调之间的关系在没有ESA的女性中一致较低且不显著。在ESA女性中，OT可能会积极调节MRMD病理学。
Oxytocin (OT), associated with affiliation and social bonding, social salience, and stress/pain regulation, may play a role in the pathophysiology of stress-related disorders, including menstrually-related mood disorders (MRMD's). Adverse impacts of early life sexual abuse (ESA) on adult attachment, affective regulation, and pain sensitivity suggest ESA-related OT dysregulation in MRMD pathophysiology. We investigated the influence of ESA on plasma OT, and the relationship of OT to the clinical phenomenology of MRMD's. Compared to MRMD women without ESA (n=40), those with ESA (n=20) displayed significantly greater OT [5.39 pg/mL (SD, 2.4) vs. 4.36 pg/mL (SD, 1.1); t (58) = −2.26, p =.03]. In women with ESA, OT was significantly, inversely correlated with premenstrual psychological and somatic symptoms (r's = −.45 to −.64, p's < .05). The relationship between OT and premenstrual symptomatology was uniformly low and non-significant in women without ESA. In women with ESA, OT may positively modulate MRMD symptomatology.