Pre-trauma individual differences in extinction learning predict posttraumatic stress
Pre-trauma individual differences in extinction learning predict posttraumatic stress
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DOI：
10.1016/j.brat.2012.11.004
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发表时间：
2013-02-01
影响因子：
4.1
通讯作者：
Hermans, Dirk
中科院分区：
文献类型：
--
作者：
Lommen, Miriam J. J.;Engelhard, Iris M.;Hermans, Dirk
在创伤事件之后，许多人遭受心理困扰，但只有少数人发展为创伤后应激障碍（PTSD）。创伤前恐惧条件反射的个体差异，最明显的是减少消退学习，已被认为在PTSD的病因学中起着重要作用。然而，缺乏前瞻性数据。在这项研究中，我们前瞻性地测试了减少灭绝是否是后期创伤后应激的预测因子。荷兰士兵（N = 249）进行了为期四个月的部署到阿富汗前的条件反射任务，评估灭绝学习的个体差异。回家后，测量创伤后压力。结果表明，减少灭绝学习部署前预测随后的PTSD症状的严重程度，超过部署前的压力症状，神经质，并暴露于压力源部署。研究结果表明，减少消退学习可能在PTSD的发展中发挥作用。(C)2012爱思唯尔有限公司保留所有权利。
In the aftermath of a traumatic event, many people suffer from psychological distress, but only a minority develops posttraumatic stress disorder (PTSD). Pre-trauma individual differences in fear conditioning, most notably reduced extinction learning, have been proposed as playing an important role in the etiology of PTSD. However, prospective data are lacking. In this study, we prospectively tested whether reduced extinction was a predictor for later posttraumatic stress. Dutch soldiers (N = 249) were administered a conditioning task before their four-month deployment to Afghanistan to asses individual differences in extinction learning. After returning home, posttraumatic stress was measured. Results showed that reduced extinction learning before deployment predicted subsequent PTSD symptom severity, over and beyond degree of pre-deployment stress symptoms, neuroticism, and exposure to stressors on deployment. The findings suggest that reduced extinction learning may play a role in the development of PTSD. (C) 2012 Elsevier Ltd. All rights reserved.