Breast cancer. Importance of adequate surgical excision prior to radiotherapy in the local control of breast cancer in patients treated conservatively.
Breast cancer. Importance of adequate surgical excision prior to radiotherapy in the local control of breast cancer in patients treated conservatively.
复制标题
乳腺癌。
DOI：
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发表时间：
1992
影响因子：
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通讯作者：
Gurmukh J. Sadarangani
中科院分区：
文献类型：
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作者：
Nametallah A. Ghossein;Seymour Alpert;Jose Barba;P. Pressman;P. Stacey;Eileen Lorenz;Mirela Shulman;Gurmukh J. Sadarangani
在 503 名患者中研究了放疗前乳腺癌切除的范围作为局部复发的危险因素。三百二十三个肿瘤（62%）被切除了最小的组织边缘（肿瘤切除术）。 142 名患者 (27%) 接受了广泛切除，56 名患者 (11%) 接受了象限切除术。所有组的肿瘤分期、大小和放射治疗均相似。 41% 的肿瘤切除术涉及切缘，而广泛切除组和象限切除组分别只有 14% 和 7% 涉及切缘。肿瘤切除术的局部失败率为 15%，广泛切除术的局部失败率为 7%，象限切除术的局部失败率为 5%。在 T1 导管癌中，切除大于 5 cm 的患者中只有 4% 出现复发。较小的切除有 20% 的复发率。放疗前的切除范围是复发的重要危险因素。失败与切除的乳腺组织数量成反比。应不鼓励进行狭窄切除，因为仍然存在较大的肿瘤负荷，可能无法通过放射线灭菌。
The extent of excision performed for mammary carcinoma prior to radiotherapy as a risk factor for local recurrence was studied in 503 patients. Three hundred twenty-three tumors (62%) were excised with a minimal rim of tissue (tumorectomy). One hundred forty-two patients (27%) had wide excision and 56 (11%) had quadrantectomy. Tumor stage, size, and radiation treatment were similar for all groups. Forty-one percent of tumorectomies had involved margins, and only 14% and 7% were involved in the wide excision and quadrantectomy groups, respectively. Local failure was 15% for tumorectomy, 7% for wide excision, and 5% for quadrantectomy. In T1 ductal carcinoma, only 4% of those with excisions greater than 5 cm had recurrences. Lesser excision had 20% recurrence. Extent of excision before radiotherapy is an important risk factor for recurrence. Failure was inversely proportional to the amount of breast tissue resected. Narrow excision should be discouraged since a larger tumor burden remains that may not be sterilized by radiation.
影响因子：
158.5
作者：
FISHER, B;REDMOND, C;SIDOROVICH, L
通讯作者：
SIDOROVICH, L