Metastatic breast cancer shows different immunohistochemical phenotype according to metastatic site
Metastatic breast cancer shows different immunohistochemical phenotype according to metastatic site
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DOI：
10.1177/030089161009600308
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发表时间：
2010-05-01
期刊：
影响因子：
1.9
通讯作者：
Jeong, Joon
中科院分区：
文献类型：
--
作者：
Koo, Ja Seung;Jung, Woohee;Jeong, Joon
目标和背景。本研究旨在评估原发性和转移性乳腺癌中免疫组化标记物的状态，并确定转移性乳腺癌的器官特异性特征。方法：收集13例原发性和转移性乳腺癌配对标本及34例转移性乳腺癌标本。在13例配对原发性和转移性乳腺癌的分析中，雌激素受体和孕激素受体丢失各有1例（7.7%）。雄激素受体丢失和获得分别在2例（15.4%）病例中观察到。HER-2与原发性和转移性肿瘤的符合率为100%。转移性乳腺癌仅2例（15.4%）表达C-kit。34例转移性乳腺癌按免疫组化染色结果分为三阴性（ER-、PR-、HER-2-）、HER-2+、ER+或PR+/HER-2-型，脑转移以HER-2型（66.7%）为主，肝转移以ER+或PR+/HER-2-型（75.0%）为主。骨转移以三阴性型（44.4%）和ER+或PR+/HER-2-型（55.6%）为主，肺转移以三阴性型和ER+或PR +/HER-2-型为主。转移性乳腺癌根据转移部位表现出不同的免疫组化表型（P = 0.048）。可在www.tumorionline.it上获得免费全文
Aims and background. The study was performed to assess the status of immunohistochemical markers in primary and metastatic breast cancer and to determine the organ-specific characteristics of metastatic breast cancer.Methods. Samples from 13 cases of paired primary and metastatic breast cancer and 34 cases of metastatic breast cancer were included.Results. In the analysis of 13 cases of paired primary and metastatic breast cancer, estrogen receptor and progesterone receptor loss were noted in 1 (7.7%) case each. Androgen receptor loss and gain was noted in 2 (15.4%) cases, respectively. HER-2 showed 100% concordance with primary and metastatic tumors. C-kit was demonstrated in only 2 (15.4%) cases of metastatic breast cancer. In the analysis of 34 cases of metastatic breast cancer, when classified into triple-negative type (ER-, PR-, and HER-2-), HER-2+ type, and ER+ or PR+/HER-2- type according to immunohistochemical stain results, HER-2 type (66.7%) in brain metastasis and ER+ or PR+/HER-2-type (75.0%) in liver metastasis were predominant. Bone metastasis was composed of triple negative type (44.4%) and ER+ or PR+/HER-2-type (55.6%), and lung metastasis showed all of three subtypes in similar proportions.Conclusions. Metastatic breast cancer shows different immunohistochemical phenotypes according to metastatic site (P = 0.048). Free full text available at www.tumorionline.it