Alpha beta and gamma delta T-cell networks and their roles in natural resistance to viral infections.
Alpha beta and gamma delta T-cell networks and their roles in natural resistance to viral infections.
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Alpha beta 和 gamma delta T 细胞网络及其在自然抵抗病毒感染中的作用。
DOI：
10.1111/j.1600-065x.1997.tb01008.x
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发表时间：
1997
影响因子：
8.7
通讯作者：
Selin,LK
中科院分区：
文献类型：
--
作者：
Welsh,RM;Lin,MY;Lohman,BL;Varga,SM;Zarozinski,CC;Selin,LK
αβ和γδT细胞群和自然杀伤(NK)细胞都包括产生干扰素γ的细胞毒淋巴细胞，它们能对病毒感染做出积极反应。我们在这里展示了所有三个种群都可以在感染早期就提供对病毒的“自然抵抗力”，并描述了T-Tell种群是如何调节来提供这一功能的。γδT细胞在控制痘苗病毒(VV)感染方面发挥了作用，因为γδT细胞敲除小鼠在感染后3-4天VV的滴度比正常小鼠高得多。我们对T细胞对病毒的反应的研究揭示了一个由T细胞组成的相互作用的网络，该网络在系统感染期间基本上受到调节。有一个与大规模病毒特异性CD8 T细胞反应相关的诱导期，即T细胞对激活诱导的细胞死亡(AICD)敏感的凋亡阶段。沉默阶段，在此期间T细胞数量和激活状态减少，以及。最后，记忆阶段与病毒特异性记忆细胞毒性T淋巴细胞前体(PCTL)的非常稳定的保存有关。用异源病毒感染One-HUS免疫的小鼠，可导致两种病毒之间交叉反应的记忆CTL选择性扩大，但在再次建立稳态后，对第一种病毒的记忆减少和定量改变。我们的结果表明，在第二种病毒感染的早期阶段，T细胞的记忆在异种病毒之间的交叉反应中既介导了免疫病理学又介导了保护性免疫。因此，记忆αβT细胞可以像γδT细胞和NK细胞一样，对病毒感染提供自然免疫。
Both αβ and γδ T‐cell populations and natural killer (NK) cells include cytotoxic, interferon (IFN)‐γ‐producing lymphocytes that actively respond to viral infections. We show here that all three populations can provide “natural resistance“ of viruses very early in infection and describe how the T‐tell populations are modulated TO provide this function. γδ T cells were shown to play a role in controlling vaccinia virus (VV) infections, as VV grew to much higher titers in γδ T‐cell knockout mice than in normal mice 3–4 days post‐infection. Our studies of the of T‐cell responses to viruses revealed an interactive network of T cells that is modulated substantially during systemic infections. There is an induction phase associated with a massive virus‐specific CD8 T‐cell response, an apoptosis phase during which the T cells become sensitized to activation‐induced ceil death (AICD). a silencing phase, during which the T‐cell number and activation state is reduced, and. finally, a memory phase associated with the very stable preservation of virus‐specific memory cytotoxic T‐lymphocyte precursors (pCTL). Infection of mice immune to one‐H US with a heterologous virus leads to a selective expansion of memory CTL cross‐reacting between the two viruses, but, after homeostasis is again established, there is a quantitative reduction and quantitative alteration of memory to the first virus. Our results suggest that memory of T cells cross‐reactive between heterologous viruses mediate both immunopathology and protective immunity at early stages of the second viruses infection. Thus, memory αβ T cells can, like γδ T cells and NK cells, provide natural immunity to viral infections.