Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity.
Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity.
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DOI：
10.1016/j.xjidi.2021.100064
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Zhang LJ
中科院分区：
文献类型：
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作者：
Guo Z;Yang Y;Liao Y;Shi Y;Zhang LJ
肥胖在全球范围内是一种日益流行的疾病，也被认为是导致包括牛皮癣(PSO)和特应性皮炎(AD)在内的炎症性皮肤病的主要环境因素。此外，肥胖会恶化这些炎症性皮肤病的病程，并损害其治疗反应。越来越多的证据表明，肥大的脂肪细胞和浸润性免疫细胞分泌各种分子，包括脂肪酸和脂肪因子，如瘦素、脂联素和一系列调节我们免疫系统的细胞因子/趋化因子。在这篇综述中，我们描述了脂肪肥大如何导致肥胖的慢性低度炎症状态，以及肥胖相关的炎症因子如何参与PSO和/或AD的发病机制。最后，我们讨论了抗菌肽、机械应力和快速扩张导致的表皮屏障功能受损以及真皮脂肪在调节皮肤炎症中的潜在作用。综上所述，这篇综述总结了肥胖与PSO和AD发病机制的关系，强调了脂肪组织在皮肤中潜在的重要但被忽视的免疫调节作用。
Obesity is a growing epidemic worldwide, and it is also considered a major environmental factor contributing to the pathogenesis of inflammatory skin diseases, including psoriasis (PSO) and atopic dermatitis (AD). Moreover, obesity worsens the course and impairs the treatment response of these inflammatory skin diseases. Emerging evidence highlights that hypertrophied adipocytes and infiltrated immune cells secrete a variety of molecules, including fatty acids and adipokines, such as leptin, adiponectin, and a panel of cytokines/chemokines that modulate our immune system. In this review, we describe how adipose hypertrophy leads to a chronic low-grade inflammatory state in obesity and how obesity-related inflammatory factors are involved in the pathogenesis of PSO and/or AD. Finally, we discuss the potential role of antimicrobial peptides, mechanical stress and impairment of epidermal barrier function mediated by fast expansion, and dermal fat in modulating skin inflammation. Together, this review summarizes the current literature on how obesity is associated with the pathogenesis of PSO and AD, highlighting the potentially important but overlooked immunomodulatory role of adipose tissue in the skin.