Basic indices of spleen immune activity in natural populations of Norway rats (Rattus norvegicus berkenhout, 1769) in Serbia
Basic indices of spleen immune activity in natural populations of Norway rats (Rattus norvegicus berkenhout, 1769) in Serbia
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塞尔维亚挪威大鼠（Rattusnorvegicusberkenhout，1769）自然群体脾脏免疫活性的基本指标
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
D. Kataranovski
中科院分区：
文献类型：
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作者：
M. Kataranovski;I. Mirkov;L. Zolotarevski;Aleksandra Popov;S. Belij;J. Stosić;D. Kataranovski
脾免疫活性的基本参数（脾重量，脾室的组织形态学，和体外有丝分裂原诱导的脾细胞增殖能力）进行了评价，在成年人的野生挪威大鼠从城市栖息地和实验室大鼠品系获得相同的数据进行比较。一个更广泛的相对脾脏质量和差异的组织形态学特征，以及差异的水平和模式的脾细胞对外源性刺激的反应，注意到在脾脏的野生挪威大鼠。在野生大鼠中增强和低水平免疫相关的脾活性的证据证明了来自自然种群的大鼠中脾免疫活性变化的复杂性。
Basic parameters of spleen immune activity (spleen weight, histomorphology of splenic compartments, and mitogen-induced splenocyte proliferative capacity in vitro) were evaluated in adult individuals of wild Norway rats from urban habitats and compared to the same data obtained in laboratory rat strains. A wider range of relative spleen mass and differential histomorphological characteristics, together with differences in the level and pattern of responsiveness of splenocytes to exogenous stimulation, were noted in spleens of wild Norway rats. Evidence of both enhanced and low- level immune-relevant spleen activity in wild rats demonstrates the complexity of changes in spleen immune activity in rats from natural populations.