Family history of cancer and stomach cancer risk
Family history of cancer and stomach cancer risk
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DOI：
10.1002/ijc.23688
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发表时间：
2008-09-15
影响因子：
6.4
通讯作者：
Negri, Eva
中科院分区：
文献类型：
--
作者：
Foschi, Roberto;Lucenteforte, Ersilia;Negri, Eva
一级亲属中有胃癌家族史会增加患胃癌的风险，但根据年龄、性别和亲属类型，以及其他癌症家族史的作用，关于胃癌风险的变化仍存在不确定性。我们使用1997年至2007年在意大利进行的一项多中心病例对照研究的数据对这一问题进行了调查，研究对象为230例年龄不超过80岁的组织学证实的胃癌病例和547例因急性非肿瘤性疾病住院的对照。使用调整性别、年龄、采访年份、教育程度、体重指数（BMI）、吸烟和兄弟姐妹篇数量影响的逻辑回归模型来估计胃癌的优势比（OR）。相对于无病史的受试者，有胃癌家族史的受试者的OR为2.5（95%置信区间（CI）1.5-4.2）。根据先证者或受影响亲属的性别或年龄，或吸烟习惯，BMI和受教育程度，未出现显著异质性。如以前的研究所示，当受影响的亲属是兄弟姐妹（OR=5.1，95%CI：1.3-20.6）而不是父母（OR = 2.2，95%CI：1.2-3.9）时，OR更高，尽管异质性检验不显著。在任何其他部位有癌症家族史的受试者中，胃癌风险均未增加。除胃外的所有部位的OR为1.0（95% CI：0.7-1.4）。(C)2008 Wiley-Liss，Inc.
A family history of stomach cancer in first-degree relatives increases the risk of stomach cancer, but uncertainties remain as concerns the variation of (fie risk according to age, sex and type of relative, as well as on the role of family history of other cancers. We investigated the issue using data from a multicentric case-control study conducted in Italy between 1997 and 2007 on 230 cases aged not more than 80 years, with histologically confirmed incident gastric cancer and 547 controls admitted to hospital for acute, non neoplastic conditions. Logistic regression models adjusted for the effect of sex, age, year of interview, education, body mass index (BMI), tobacco smoking and number of brothers and sisters were used to estimate the odds ratios (OR) of stomach cancer. Relative to subjects with no history, those with a family history of gastric cancer had an OR of 2.5 (95% confidence interval (CI) 1.5-4.2). No significant heterogeneity emerged according to sex or age of the proband or of the affected relative, or smoking habits, BMI and education of (lie proband. As suggested from previous studies the OR was higher when the affected relative was a sibling (OR=5.1, 95% CI: 1.3-20.6) rather than a parent (OR = 2.2, 95% CI: 1.2-3.9), although the heterogeneity test was not significant. The risk of stomach cancer was not increased in subjects with a family history of cancer at any other site. The OR for all sites excluding stomach was 1.0 (95% Cl: 0.7-1.4). (C) 2008 Wiley-Liss, Inc.