LOW T3 SYNDROME IN PATIENTS CHRONICALLY TREATED WITH AN IODINE-CONTAINING DRUG, AMIODARONE
LOW T3 SYNDROME IN PATIENTS CHRONICALLY TREATED WITH AN IODINE-CONTAINING DRUG, AMIODARONE
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DOI：
10.1111/j.1365-2265.1978.tb03569.x
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发表时间：
1978-01-01
影响因子：
3.2
通讯作者：
BECKERS, C
中科院分区：
文献类型：
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作者：
JONCKHEER, MH;BLOCKX, P;BECKERS, C
接受含碘药物胺碘酮治疗的心脏病患者会出现显著的碘超负荷，停药后可持续数月。部分患者出现甲状腺功能亢进，其他患者出现甲状腺功能减退。在甲状腺功能亢进或减退患者中，甲状腺功能指数被修改，通常在这些情况下观察到。在服用胺碘酮期间或停药后甲状腺功能保持正常，但仍受到I超负荷影响的患者中，观察到低T3 [三碘甲状腺原氨酸]综合征，这种状态的特征是总T4 [甲状腺素]高，游离T4低，T3树脂摄取正常，总T3低，游离T3正常，高r-T3 [反向T3]和相对TSH[促甲状腺激素]对TRH [促甲状腺激素释放激素]无反应性。
Cardiac patients treated with the I-containing drug amiodarone undergo a significant I overload which can last for months after drug withdrawal. Some patients developed hyperthyroidism and others hypothyroidism. In the hyper- or hypothyroid patients, the indices of thyroid function were modified as usually observed in these situations. In the patients remaining euthyroid while taking amiodarone or after its withdrawal, but still under its influence as shown by the I overload, a low-T3 [triiodothyronine] syndrome was observed, this state was characterized by a high total T4 [thyroxine], a low free T4, a normal T3 resin uptake, a low total T3, a normal free T3, a high r-T3 [reverse T3] and a relative TSH[thyroid stimulating hormone]-unresponsiveness to TRH [thyrotropin releasing hormone].