Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. ASTS/ASTP EBV-PTLD Task Force and The Mayo Clinic Organized International Consensus Development Meeting.
Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. ASTS/ASTP EBV-PTLD Task Force and The Mayo Clinic Organized International Consensus Development Meeting.
复制标题
Epstein-Barr 病毒引起的移植后淋巴细胞增殖性疾病。
作者：
C. Payá;J. Fung;M. Nalesnik;E. Kieff;M. Green;G. Gores;T. Habermann;P. H. Wiesner;J. Swinnen;E. Woodle;J. Bromberg
EB病毒引起的移植后淋巴组织增生性疾病（EBV-PTLD）仍然是高危患者实体器官移植后的主要并发症。尽管确定了易使患者发生EBV-PTLD的危险因素，但我们对其发病机制的认识有限，建立诊断的可变标准以及缺乏针对EBV-PTLD预防和治疗的随机研究阻碍了这种移植并发症的最佳管理。本综述总结了目前对EBV-PTLD的认识，并作为两个独立的国际会议对这一主题的结果，并为未来的研究领域提供了建议。
Epstein-Barr virus-induced posttransplant lymphoproliferative disease (EBV-PTLD) continues to be a major complication after solid organ transplantation in high-risk patients. Despite the identification of risk factors that predispose patients to develop EBV-PTLD, limitations in our knowledge of its pathogenesis, variable criteria for establishing the diagnosis, and lack of randomized studies addressing the prevention and treatment of EBV-PTLD hamper the optimal management of this transplant complication. This review summarizes the current knowledge of EBV-PTLD and, as a result of two separate international meetings on this topic, and provides recommendations for future areas of study.