Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum
Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum
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DOI：
10.1016/j.foodchem.2006.01.003
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发表时间：
2007-01-01
期刊：
影响因子：
8.8
通讯作者：
Kondo, Ryuichiro
中科院分区：
文献类型：
--
作者：
Liu, Jie;Shimizu, Kuniyoshi;Kondo, Ryuichiro
灵芝乙醇提取物对睾酮诱导的去势大鼠腹侧前列腺生长有抑制作用，对5 α-还原酶1型和2型同工酶有抑制作用，但对双氢睾酮无抑制作用。活性导向分级分离和薄层色谱分析表明，其体内活性成分为三萜类化合物。这些结果表明，G.灵芝可能是治疗良性前列腺增生的有效成分。(c)2006爱思唯尔有限公司版权所有。
The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5 alpha-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia. (c) 2006 Elsevier Ltd. All rights reserved.