Long term survival results for gastric GIST: is laparoscopic surgery for large gastric GIST feasible?
Long term survival results for gastric GIST: is laparoscopic surgery for large gastric GIST feasible?
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DOI：
10.1186/1477-7819-10-230
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发表时间：
2012-10-31
影响因子：
3.2
通讯作者：
Kwon HC
中科院分区：
文献类型：
--
作者：
Kim KH;Kim MC;Jung GJ;Kim SJ;Jang JS;Kwon HC
近年来，腹腔镜切除相对较小的胃肠道间质瘤（GIST）已被广泛接受为微创手术。然而，迄今为止尚未发表关于这种手术治疗大型胃GIST的长期安全性和有效性的报告。在1998年7月至2011年1月期间，104例因胃GIST接受切除术的连续患者入选本回顾性研究。我们评估了临床病理学特征、术后结果、患者生存率和肿瘤复发。在纳入研究的104例胃GIST患者中，有47例男性和57例女性，平均年龄为59.8岁。64例（61.5%）患者有肿瘤相关症状。10例患者被纳入第1组，49例被纳入第2组，15例被纳入第3a组，9例被纳入第5组，14例被纳入第6a组，7例被纳入第6 b组。有1例轻微并发症，无死亡。在5例患者中观察到复发，中位随访期为49.3个月（范围，8.4至164.4）。104例患者的5年总生存率和无病生存率分别为98.6%和94.8%。腹腔镜手术与开腹手术比较大肿瘤（5-10 cm）时，年龄、肿瘤大小、肿瘤部位、住院时间差异有统计学意义。腹腔镜与开腹手术治疗5- 10 cm大肿瘤的5年生存率差异无统计学意义。腹腔镜手术是治疗胃肠道间质瘤的有效方法。此外，对于大于5 cm的胃GIST，腹腔镜手术可以作为开放手术的可接受替代方法。
Recently, laparoscopic resection for relatively small sized gastric gastrointestinal stromal tumors (GISTs) has been widely accepted as minimally invasive surgery. However, no report on the long-term safety and efficacy of this surgery for large sized gastric GISTs has been published to date. Between July 1998 and January 2011, 104 consecutive patients who underwent resection for gastric GISTs were enrolled in this retrospective study. We assessed the clinicopathological characteristics, postoperative outcomes, patient survival, and tumor recurrence. Of the 104 patients with gastric GISTs who were included in the study, there were 47 males and 57 females whose mean age was 59.8 years. Sixty-four patients (61.5%) had symptoms associated with tumor. Ten patients included in the group 1, 49 in the group 2, 15 in the group 3a, 9 in the group 5, 14 in the group 6a, and 7 in the group 6b. There was one minor complication and no mortalities. Recurrence was noted in 5 patients, with a median follow-up period of 49.3 months (range, 8.4 to 164.4). The 5-year overall and disease free survival rates of 104 patients were 98.6% and 94.8%, respectively. When comparing large tumor (5–10 cm) between laparoscopic and open surgery, there were statistically differences in age, tumor size, tumor location, and length of hospitalization. There were no statistical differences in the 5-year survival rate between laparoscopic and open surgery for large tumor (5-10cm). Laparoscopic surgery is feasible and effective as an oncologic treatment of gastric GISTs. Moreover, laparoscopic surgery can be an acceptable alternative to open methods for gastric GISTs of size bigger than 5 cm.
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影响因子：
--
作者：
Huguet, Kevin L.;Rush, Robert M., Jr.;Harold, Kristi L.
通讯作者：
Harold, Kristi L.
影响因子：
2.5
作者：
Hyung, WJ;Lim, JS;Noh, SH
通讯作者：
Noh, SH
DOI：
10.1007/s00464-001-8319-z
发表时间：
2002-05-01
影响因子：
3.1
作者：
Matthews, BD;Walsh, RM;Heniford, BT
通讯作者：
Heniford, BT
影响因子：
2.5
作者：
Mochizuki, Y;Kodera, Y;Kato, T
通讯作者：
Kato, T
影响因子：
3.8
作者：
An, J. Y.;Choi, M. G.;Kim, S.
通讯作者：
Kim, S.