Primary effusion Burkitt's lymphoma with t(8;22) in a patient with hepatitis C virus-related cirrhosis
Primary effusion Burkitt's lymphoma with t(8;22) in a patient with hepatitis C virus-related cirrhosis
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DOI：
10.1016/s0046-8177(97)90287-2
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发表时间：
1997-01-01
期刊：
影响因子：
3.3
通讯作者：
Mecucci, C
中科院分区：
文献类型：
--
作者：
Ascoli, V;LoCoco, F;Mecucci, C
丙型肝炎病毒（HCV）感染可能通过尚不清楚的发病机制而并发非霍奇金淋巴瘤。我们描述了一名 HCV 相关肝硬化患者的病例，该患者在没有免疫缺陷或自身免疫的情况下，出现了伯基特型原发性渗出性淋巴瘤 (PEL)，局限于腹膜腔。腹腔穿刺术随后进行免疫表型分析、核型分析和分子研究，使我们能够诊断出具有免疫球蛋白重链基因 t(8;22)(q24;q11) 易位和克隆重排的小型非裂解 B 细胞淋巴瘤（CD20(+)、CD24(+)、CD10(+)、CD5(-)、CD23(-)、lambda(+)）。在淋巴瘤细胞内未发现 HCN-RNA、EB 病毒和卡波西肉瘤相关疱疹病毒。腹水中 HCV-RNA 的发现表明 HCV 与淋巴瘤的发展之间存在联系，HCV 对腹膜内 B 细胞克隆扩张发挥持续抗原刺激的作用。版权所有 (C) 1997 W.B.桑德斯公司。
Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma through yet unknown pathogenetic mechanisms. We describe the case of a patient with HCV-related cirrhosis who developed a primary effusion lymphoma (PEL) of Burkitt's type confined to the peritoneal cavity, in the absence of immunodeficiency or autoimmunity. Paracentesis followed by immunophenotyping, karyotyping, and molecular studies allowed us to diagnose a small noncleaved B-cell lymphoma (CD20(+), CD24(+), CD10(+), CD5(-), CD23(-), lambda(+)) with the t(8; 22) (q24; q11) translocation and clonal rearrangement of the immunoglobulin heavy chain gene. HCN-RNA, Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus were not identified within lymphoma cells. The finding of HCV-RNA in the ascitic fluid suggests a link between HCV and development of lymphoma with HCV playing the role of persistent antigenic stimulation to intraperitoneal B-cell clonal expansion(s). Copyright (C) 1997 by W.B. Saunders Company.