Epithelial-mesenchymal interactions in intestinal epithelial differentiation.
Epithelial-mesenchymal interactions in intestinal epithelial differentiation.
复制标题
肠上皮分化中的上皮-间质相互作用。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
K. Haffen
中科院分区：
文献类型：
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作者：
M. Kedinger;P. simon;F. Bouziges;K. Haffen
肠祖细胞复杂的形态发生过程以及伴随的结构和功能分化依赖于组织间的相互作用。描述了上皮和间充质原基之间的异种或异位重组体的几种实验模型。它们使我们能够阐明这些组织成分在形态发生、上皮分化和乳腺癌引起的反应中各自的作用。在组织相互作用的机制中，假设通过细胞外基质可能介导许可和指导性信息。支持这一观点的论据是通过观察肠道发育和分化过程中基质分子的组成变化来提供的。另一方面，体外实验数据强调上皮细胞和间充质细胞群体之间的实际接触的作用和间充质对基底膜形成的重要性。
The complex morphogenetic events and the concomitant structural and functional differentiation of intestinal progenitor cells are dependent on tissue interactions. Several experimental models of hetero-species or -topic recombinants between epithelial and mesenchymal anlagen are described. They enabled us to elucidate the respective roles of these tissue components in morphogenesis, epithelial differentiation, and hormone-elicited responses. Among the mechanisms of tissue interactions, the possible mediation of permissive and instructive information via the extracellular matrix is postulated. Arguments in favor of this are provided by the observation of compositional changes in matrix molecules during intestinal development and differentiation. On the other hand, in vitro experimental data emphasize the role of actual contacts between epithelial and mesenchymal cell populations and the importance of the mesenchyme for basement membrane formation.
细胞外基质影响基因表达的组合过程：一个假设。
DOI：
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发表时间：
1982
期刊：
Journal of craniofacial genetics and developmental biology
影响因子：
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作者：
Slavkin,HC
通讯作者：
Slavkin,HC