Organ transplantation in persons with HIV.
Organ transplantation in persons with HIV.
复制标题
艾滋病毒感染者的器官移植。
DOI：
10.1097/qad.0000000000002518
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Stosor,Valentina
中科院分区：
文献类型：
--
作者：
Kumar,RebeccaN;Stosor,Valentina
通过目前的抗逆转录病毒治疗，新诊断的艾滋病毒感染者（PWH）的寿命接近未感染者的寿命。然而，与疾病和病毒本身相关的代谢异常以及衰老合并症已导致终末器官疾病和器官衰竭，成为发病和死亡的主要原因。实体器官移植对于器官衰竭的感染者来说是一种挽救生命的疗法，《艾滋病毒器官政策公平法案》的批准为感染者捐献和接受器官提供了并扩大了机会。将回顾目前的 PWH 器官移植环境，并讨论未来的研究和治疗方向。
With current antiretroviral therapy, the lifespan of newly diagnosed persons with HIV (PWH) approaches that of uninfected persons. However, metabolic abnormalities related to both the disease and the virus itself, along with comorbidities of aging, have resulted in end-organ disease and organ failure as a major cause of morbidity and mortality. Solid organ transplantation is a life-saving therapy for PWH who have organ failure, and the approval of the HIV Organ Policy Equity Act has opened and expanded opportunities for PWH to donate and receive organs. The current environment of organ transplantation for PWH will be reviewed and future directions of research and treatment will be discussed.