PPAR Gamma and Hepatic Stellate Cells.
PPAR Gamma and Hepatic Stellate Cells.
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DOI：
10.1186/1476-5926-2-s1-s7
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发表时间：
2004-01-14
期刊：
影响因子：
--
通讯作者：
Tsukamoto H
中科院分区：
文献类型：
--
作者：
Hazra S;Miyahara T;Rippe RA;Tsukamoto H
肝星状细胞（HSC）在纤维化中的活化涉及不同的形态学和生化变化。这种激活需要几个转录因子的活性的协调变化。过氧化物酶体增殖物激活受体γ（PPAR γ）是这样一种因子，其活性在活化的HSC中降低。PPAR γ配体抑制HSC活化的几种标志物，例如胶原蛋白和α平滑肌肌动蛋白（α-SMA）的表达、细胞增殖和迁移。PPAR γ的表达本身也抑制HSC活化。这些发现支持了PPAR γ在活化HSC向其静止状态逆转中的作用。
Activation of Hepatic stellate cells (HSC) in fibrogenesis involves distinct morphological and biochemical changes. This activation requires the coordinated changes in activity of several transcription factors. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one such factor whose activity is decreased in activated HSC. PPAR gamma ligands suppress several markers of HSC activation such as expression of collagen and alpha smooth muscle actin (alpha-SMA), cell proliferation and migration. Expression of PPAR gamma, per se, also inhibits HSC activation. These findings support the role of PPAR gamma in reversion of activated HSC toward their quiescent state.