Anti-peptide antibodies detect oncogene-related proteins in urine.
Anti-peptide antibodies detect oncogene-related proteins in urine.
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抗肽抗体可检测尿液中与癌基因相关的蛋白质。
DOI：
10.1073/pnas.82.23.7924
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发表时间：
1985
影响因子：
11.1
通讯作者：
Lerner,RA
中科院分区：
文献类型：
--
作者：
Niman,HL;Thompson,AM;Yu,A;Markman,M;Willems,JJ;Herwig,KR;Habib,NA;Wood,CB;Houghten,RA;Lerner,RA
根据癌基因核酸序列预测的一些合成肽的抗血清已被用于对483例癌症患者、孕妇和正常对照的尿样进行免疫相关蛋白的筛查。在肿瘤形成和妊娠期间，癌基因相关蛋白水平升高。对这些癌基因相关蛋白的差异检测表明，单抗组合可能提供一种方便的、非侵入性的手段来检测、分类和分期各种恶性肿瘤，并可能在妊娠期间跟踪胎儿发育。
Antisera to a number of synthetic peptides predicted from nucleic acid sequences of oncogenes have been used to screen 483 urine samples of cancer patients, pregnant women, and normal controls for the presence of immunologically related proteins. Increased levels of oncogene-related proteins are found during neoplasia and pregnancy. The differential detection of these oncogene-related proteins indicates that panels of monoclonal antibodies may provide a convenient noninvasive means of detecting, classifying, and staging a wide variety of malignancies and may be useful in following fetal development during pregnancy.